Results 111 to 120 of about 8,852,576 (377)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

ENGINEERING EDUCATION: PRACTICE-ORIENTED APPROACH

open access: yesВысшее образование в России, 2017
The paper substantiates the need to strengthen the practical orientation of engineering education in modern socio-economic conditions. The paper shows that introduction of context-related tasks during classroom hours correspond to the implementation of ...
N. N. Dvulichanskaya, V. B. Piasetsky
doaj  

Revision of engineering education for 21st century

open access: yesآموزش مهندسی ایران, 2012
What knowledge, skills, and attitudes should students have upon graduation? And how can we ascertain that they have acquired these capabilities? These have been fundamental questions in engineering education during the last two decades.
H. Memarian
doaj   +1 more source

Using Digital Twin Technology in Engineering Education – Course Concept to Explore Benefits and Barriers

open access: yes, 2020
Digital Twin (DT) technology is an essential technology related to the Industry 4.0. In engineering education, it is important that the curricula are kept up-to-date.
Antti Liljaniemi, Heikki Paavilainen
semanticscholar   +1 more source

Walking Through the Method Zoo: Does Higher Education Really Meet Software Industry Demands? [PDF]

open access: yes, 2019
Software engineering educators are continually challenged by rapidly evolving concepts, technologies, and industry demands. Due to the omnipresence of software in a digitalized society, higher education institutions (HEIs) have to educate the students ...
Conte, T.   +7 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

The importance of understanding computer analyses in civil engineering [PDF]

open access: yes, 2013
Sophisticated computer modelling systems are widely used in civil engineering analysis. This paper takes examples from structural engineering, environmental engineering, flood management and geotechnical engineering to illustrate the need for civil ...
Borthwick, Alistair   +4 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

A review of literature on communication skills development (CSD) in the engineering curriculum [PDF]

open access: yes, 2008
Engineering education has expanded recently to include emphasis on the development of some very specific non-technical attributes that match a strong technical base to produce well-rounded engineering graduates who are flexible and adaptable to suit the ...
Awang, Zubaidah, Othman, Rohani
core  

The Practices of Play and Informal Learning in the miniGEMS STEAM Camp [PDF]

open access: yes, 2019
Science, Technology, Engineering, and Mathematics (STEM) play an important role in the educational reform and global economy. However, STEM education lacks the hands-on laboratory in the formal middle school and high school curricula.
Frye, Michael   +2 more
core   +1 more source

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