Results 91 to 100 of about 9,714,306 (345)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
ENGINEERING EDUCATION: FORMAT CHANGE
Высшее образование в России, 2016 The necessity for changes in content and technology of engineering personnel training is discussed. The model of "new" engineering education has been developed and tested as a project at Siberian Federal University in order to find changing mechanisms in
Pavel M. Vcherashny +3 more
doaj
A review of literature on communication skills development (CSD) in the engineering curriculum [PDF]
, 2008 Engineering education has expanded recently to include emphasis on the development of some very specific non-technical attributes that match a strong technical base to produce well-rounded engineering graduates who are flexible and adaptable to suit the ...
Awang, Zubaidah, Othman, Rohani
core
Education, Entrepreneurship and Immigration: America's New Immigrant Entrepreneurs, Part II [PDF]
, 2007 Analyzes the educational backgrounds and career trajectories of immigrant entrepreneurs, finding that advanced education in science, technology, engineering, and mathematics is correlated with high rates of entrepreneurship and ...
AnnaLee Saxenian +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Traditional vocations and modern professions among Tamil Brahmans in colonial and post-colonial south India [PDF]
, 2010 Since the nineteenth century, Tamil Brahmans have been very well represented in the educated professions, especially law and administration, medicine, engineering and nowadays, information technology.
Fuller, C. J., Narasimhan, Haripriya
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Giant Leap in the Development of Higher Engineering Education in China
ECNU Review of EducationPurpose This study discusses the development of higher engineering education and its future direction following the increased enrollment in higher education institutions in China.
Zhengyang Wu (邬正阳)
doaj +1 more source