Results 81 to 90 of about 648,638 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

ENGINEERING EDUCATION: PRACTICE-ORIENTED APPROACH

Высшее образование в России, 2017
The paper substantiates the need to strengthen the practical orientation of engineering education in modern socio-economic conditions. The paper shows that introduction of context-related tasks during classroom hours correspond to the implementation of ...
N. N. Dvulichanskaya, V. B. Piasetsky
doaj  

Faculty perspectives on Future Engineering Education

, 2021
New societal challenges have emerged, and the Sustainable Development Goals present a concise summary of the engineering grand challenges (National Academy of Engineering, 2007).
Winther, Maiken,, Gumaelius, Lena,, Magnell, Marie,, Routhe, Henrik Worm,, Kolmos, Anette,   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Application of Artificial Intelligence in Engineering Education: A Systematic Review

IEEE Access
Artificial Intelligence (AI) is increasingly impacting the environment, pedagogy, and management practices in engineering education. However, literature reviews that provide a systematic review and analysis of AI in engineering education remain limited ...
Cong Liu, Guang-Chao Wang, Hong-Feng Wang   +2 more
doaj   +1 more source

Redefining engineering education: the reflective practice of product design engineering [PDF]

, 2001
The University of Glasgow and the School of Design at the Glasgow School of Art have joined forces to redefine the nature of an engineering curriculum and produce a degree program that is rich in both creative design culture and design engineering skills.
Green, G.
core  

Offering an Entrepreneurship Course to All Engineering Students: Lessons Learned from ING2030 in Puc-Chile

, 2021
All rights reserved.Entrepreneurial learning experiences have become one of the key aspects of the state of the art in engineering education. As such, technology-focused entrepreneurship courses have been incorporated to engineering curricula — both in ...
Hilliger Carrasco, Isabel, Baier Aranda, Jorge Andrés, Fleet, Constance, Melian, Constanza, Perez Sanagustin, Maria Del Mar   +4 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Control Engineering Education in Belgium

Measurement + Control, 1986
The present report gives an overview of the engineering education system in Belgian universities, and includes a more detailed discussion on control engineering education.
A van Cauwenberghe, E Noldus, J L Williams   +2 more
doaj   +1 more source