Results 141 to 150 of about 9,714,306 (345)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

CONTEMPORARY ENGINEERING EDUCATION: UNITY IN DIVERSITY

open access: yesВысшее образование в России, 2016
The paper describes new trends in global engineering education from the view of professional and social cultural diversity. Different approaches to diversity in engineering are analyzed, the importance of personal and professional life experiences for ...
Vasiliy G. Ivanov   +2 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Virtual Chemical Engineering: Guidelines for E-Learning in Engineering Education

open access: yesSeminar.net, 2010
Advanced three-dimensional virtual environment technology, similar to that used by the film and computer games industry can allow educational developers to rapidly create realistic three-dimensional, virtual environments. This technology has been used to
Damian Schofield, Edward Lester
doaj  

Metrics and Key Outcomes Related to SFAz Grant Programs [PDF]

open access: yes, 2011
Based on a grantee survey, examines the outcomes of Science Foundation Arizona's 2007-10 grants in terms of leveraged funding, jobs supported, innovation and discovery funded, and science, technology, engineering, and math (STEM) education ...

core  

Modeling student pathways in a physics bachelor's degree program

open access: yes, 2019
Physics education research has used quantitative modeling techniques to explore learning, affect, and other aspects of physics education. However, these studies have rarely examined the predictive output of the models, instead focusing on the inferences ...
Aiken, John M.   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Student search behaviour in a digital library [PDF]

open access: yes, 2006
This paper covers student search behaviour in a digital library. It was presented at the eighth international conference of engineering and product design education, in Salzburg, in ...
Grierson, H.J.   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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