Results 151 to 160 of about 648,638 (314)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Professional identity : a framework for research in engineering education

open access: yes, 2008
The development of a student’s professional identity as an engineer is key to understanding education from the student’s perspective, and framing future engineering education research.
Nouwens, Fons.   +3 more
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A systematic literature review of requirements engineering education. [PDF]

open access: yesRequir Eng, 2023
Daun M   +3 more
europepmc   +1 more source

A curriculum framework for flexible engineering degrees in South Africa

open access: yes, 2014
South Africa produces too few engineers to meet its development needs. The number of graduating engineers is slowly increasing, but is still only about 2000 per year, serving a population of over 50 million. Data from the Council on Higher Education (CHE
Shay, Suellen   +3 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Engineering education research methods to determine conceptions of engineers and of engineering.

open access: yes, 2019
Engineering education research has been categorised into the five research areas of ‘engineering epistemologies’, ‘engineering learning mechanisms’, ‘engineering learning systems’, engineering diversity and inclusiveness’, and ‘engineering assessment ...
Gumaelius, Lena   +4 more
core  

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