Results 41 to 50 of about 12,491,947 (302)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Blended learning the higher education classroom : a critical review of developments within engineering education

open access: yes, 2018
The rapid development of technology in the past two decades has had many points of contact and impact upon the global higher education sector. Technology and globalisation have unlocked entirely new directions for higher education and has provided a ...
Afsharian, Azadeh   +2 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

What Every Engineer Should Know about Engineering Education [PDF]

open access: yes, 2005
The purpose of this paper is to present the current status of the literature of engineering education. In order to accomplish this task several questions are discussed: Who publishes the documents? What are the topics of the articles published?
Osorio, Nestor L.
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Redefining engineering education: the reflective practice of product design engineering [PDF]

open access: yes, 2001
The University of Glasgow and the School of Design at the Glasgow School of Art have joined forces to redefine the nature of an engineering curriculum and produce a degree program that is rich in both creative design culture and design engineering skills.
Green, G.
core   +5 more sources

Modern mechanical engineering: research, development and education

open access: yes, 2014
This book covers modern subjects of mechanical engineering such as nanomechanics and nanotechnology, mechatronics and robotics, computational mechanics, biomechanics, alternative energies, sustainability as well as all aspects related with mechanical ...
Davim, J. Paulo, editor.   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Innovation in Engineering Educations:Today's Need, Tomorrow's Inevitability

open access: yesآموزش مهندسی ایران, 2009
During the past two decades, socio-economic changes and new technologies have had drastic impacts on higher education in general, and on engineering education in particular.
Abbas Bazargan
doaj   +1 more source

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