Results 81 to 90 of about 3,155,901 (278)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Application of Deep Learning in Civil Engineering Management. [PDF]

Comput Intell Neurosci, 2022
Zhao H.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

RWU Approves Campus Location for New SECCM Labs [PDF]

, 2017
With Trustees\u27 approval, RWU plans to break ground in spring on School of Engineering, Computing and Construction Management ...
Fitzpatrick, Edward
core   +1 more source

Driving Forces Behind Whole-Process Engineering Consulting Competitiveness Based on AHP-ISM Method

Buildings
Modern construction projects face persistent challenges with cost overruns and fragmented management across disconnected service phases. Whole-Process Engineering Consulting (WPEC) addresses these issues by integrating investment decision-making, design,
Mei Liu, Jingyi Yuan, Qihua Yang, Jiaming Wang, Yuxuan Wang, Pinchao Liao   +5 more
doaj   +1 more source

Management Engineering In Alavi Culture [PDF]

مدیریت بهره وری, 2008
Management is a behavior that the managers show according to their positions for managing the organization, and behavior is a component which is shaped and identified on the basis of thinking and value principles and which creates behavior differences ...
Mohammad bager Babaye Tlatpe
doaj  

Video Content Analysis of Human Sports under Engineering Management Incorporating High-Level Semantic Recognition Models. [PDF]

Comput Intell Neurosci, 2022
Hui R.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Coordinated Development of Population, Resources, Environment, Economy, and Society under Engineering Management Combined with Bilevel Optimization Model. [PDF]

Comput Intell Neurosci, 2022
Chen K, Chen Y.
europepmc   +1 more source