Results 81 to 90 of about 3,131,225 (327)
Proceedings of the Canadian Engineering Education Association (CEEA), 2011 This paper reports on the findings of a combined qualitative and quantitative research case study into engineering management (EM) practices in offshore Oil and Gas industry in St. John's, Newfoundland. It was designed to examine the management challenges faced by EMs in this sector, how EMs are selected, how engineers respond to being made managers ...
Paul Ryan, Leonard Lye, Amy Hsiao
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Valuing Knowledge Management Impact on Engineering Design Activities [PDF]
Knowledge Management Systems (KMS) have been developed in Engineering Designactivities in order to improve the productivity of these activities. Nevertheless it is still verydifficult to identify the impact of such Systems on the Engineering Design ...
Aurélie Dudezert, Mickaël Gardoni
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Intersubjective management in aerospace engineering
MATEC Web of Conferences, 2017 This article presents a postnonclassical approach to create the science of management processes organization in a developing society, the focus of which is “the man of culture”, i.e.
Arpentieva Mariam +2 more
doaj +1 more source
Application of Deep Learning in Civil Engineering Management. [PDF]
Comput Intell Neurosci, 2022 Zhao H.
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Town of New Durham Stormwater Management & Erosion Control Project [PDF]
, 2010 Appledore Engineering worked with the New Durham Planning Board to develop a stormwater management and erosion control ordinance and to adopt complimentary improvements to the town’s site plan review and subdivision ...
Town of Durham
core +2 more sources