Results 61 to 70 of about 3,191,010 (297)

Migrating agile methods to standardized development practice [PDF]

, 2003
Situated process and quality frame-works offer a way to resolve the tensions that arise when introducing agile methods into standardized software development engineering.
Lycett, M, Macredie, RD, Patel, C, Paul, RJ   +3 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Environmental Influencing Factors of the Realization of Engineering Construction Harmony from the Perspective of Ren–Shi–Wu: Evidence from China

Buildings
Engineering construction involves many internal factors and external environmental factors, resulting in conflict or uncoordinated problems in engineering management.
Weiwei Zuo, Ning Yan, Qiankun Wang
doaj   +1 more source

On Evidence-based Risk Management in Requirements Engineering

, 2017
Background: The sensitivity of Requirements Engineering (RE) to the context makes it difficult to efficiently control problems therein, thus, hampering an effective risk management devoted to allow for early corrective or even preventive measures ...
B Boehm, B Lawrence, BW Boehm, D Damian, D Karolak, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, M Felderer, M Kalinowski, R Wieringa, S Pfleeger, T DeMarco, T Gorschek, Y Asnar   +15 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Research of the Project Proprietor’ s Management Control of Engineering Change

SHS Web of Conferences, 2015
The problem of the engineering budgetary estimate surpass engineering cost estimate, engineering budget surpass engineering budgetary estimate, engineering final accounts surpass engineering budget in our country’s present stage of the engineering ...
Pan Yanhua, Chen Yanfan
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Editorial: Human decision-making behaviors in engineering and management: A neuropsychological perspective

Frontiers in Neuroscience, 2022
Hanliang Fu, Hanliang Fu, Gui Ye, Gui Ye, Jiayu Chen, Pin-Chao Liao   +5 more
doaj   +1 more source

ORGANIZATION OF CIVIL ENGINEERING BUSINESS MANAGEMENT SYSTEM BASED ON DIGITAL TECHNOLOGY

Научно-технические ведомости СПбГПУ: Экономические науки, 2020
It is possible to increase effectivity in the civil engineering sector, one of the most important sectors for the Economics of Russian Federation—with digital technologies.
ustinova liliya, Roman Nicolay
doaj   +1 more source