Results 41 to 50 of about 585,858 (260)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
BuildingsEngineering construction involves many internal factors and external environmental factors, resulting in conflict or uncoordinated problems in engineering management.
Weiwei Zuo, Ning Yan, Qiankun Wang
doaj +1 more source
Risk management in civil engineering [PDF]
Građevinski Materijali i Konstrukcije, 2023 Risk is involved in the whole lifecycle of a structure: design, construction, utilization, and demolition. There is a close connection between reliability and risk.
Mašović Snežana +4 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Managing engineers effectively
IEEE Transactions on Engineering Management, 1983 The professional needs of engineering personnel are investigated. Their degree of satisfaction is positively associated with overall engineering performance. All of the sixteen specific needs analyzed involve three primary issues: (1) people skills, (2) organizational structure, and (3) management style, influenced by the task to be performed and the ...
openaire +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Logistics Maturity Model for Engineering Management – Method Proposal
Management Systems in Production Engineering, 2019 The objective of the paper is to present results of research carried out on the development of a logistics maturity model for enterprises. The proposed approach allows for companies to self-assess their level of advancement of logistics processes ...
Werner-Lewandowska Karolina +1 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
International Transactions on Electrical Energy Systems, 2022 With the advancement of China’s industrial construction, the field of engineering management has also attracted more attention. However, China’s engineering management major is currently in a growing stage due to the issue of the opening years, and the ...
Dan Wang, Fengyi Han, Qi Zhao, Yinyin Lv
doaj +1 more source