Results 61 to 70 of about 1,023,504 (293)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Explanation and discovery in aerodynamics [PDF]

, 2005
The purpose of this paper is to discuss and clarify the explanations commonly cited for the aerodynamic lift generated by a wing, and to then analyse, as a case study of engineering discovery, the aerodynamic revolutions which have taken place within ...
McCabe, Gordon
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The engineering students’ use of multiple representations in mechanics problems solving at a selected public university in Rwanda

Cogent Education
The subject of physics can sometimes seem esoteric and challenging to engineering students. It would be beneficial to create a more conducive learning environment for them by combining words, mathematical equations, graphs, and diagrams to increase their
Theogene Niyomufasha, Celestin Ntivuguruzwa, Leon Rugema Mugabo   +2 more
doaj   +1 more source

Addition to the method of dimensional analysis in hydraulic problems [PDF]

Инженерно-строительный журнал, 2013
The modern engineering design, structures, and especially machines running of new technologies set to engineers the problems that require immediate solution.
A.M. Kalyakin, E.V. Chesnokova
doaj  

Engineering Mechanics Division [PDF]

Screening methods for metal oxide semiconductor field effect transistors and resistors, impact survival testing of spacecraft electronic parts, and parachute jettisoning from planetary ...

core   +1 more source

A strict error bound with separated contributions of the discretization and of the iterative solver in non-overlapping domain decomposition methods

, 2013
This paper deals with the estimation of the distance between the solution of a static linear mechanic problem and its approximation by the finite element method solved with a non-overlapping domain decomposition method (FETI or BDD).
Gosselet, Pierre, Rey, Christian, Rey, Valentine   +2 more
core   +2 more sources

Themed issue on selected papers SEG2015: part II [PDF]

, 2016
This themed issue of Geomechanics for Energy and the Environment ‘SEG-2015-Part II’, presents papers selected from extended abstracts submitted to the Symposium on Energy Geotechnics (SEG-2015) held in the Civil Engineering School of the Universitat ...
Romero Morales, Enrique Edgar, Sánchez, Marcelo   +1 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source