Results 141 to 150 of about 160,456 (265)
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Introduction to optimization analysis in hydrosystem engineering
, 2014 This book presents the basics of linear and nonlinear optimization analysis for both single and multi-objective problems in hydrosystem engineering.
Hosseinipour, Edward Zia +2 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENTAbstract - The evolution of search technologies from traditional keyword-based retrieval toward generative and answer-based paradigms has fundamentally altered digital visibility strategies. Conventional Search Engine Optimization (SEO), while still essential, is increasingly insufficient for ensuring content presence in environments dominated by ...
Gembali Manasa +4 more
openaire +1 more source
Computational engineering design under uncertainty: an aircraft conceptual design perspective [PDF]
, 2009 Presented in this thesis is a novel methodology for aircraft design optimization in the presence of uncertainty, with emphasis on the conceptual design stage.
Padulo, Mattia
core
An uncertain multidisciplinary design optimization method using interval convex models
, 2013 This article proposes an uncertain multi-objective multidisciplinary design optimization methodology, which employs the interval model to represent the uncertainties of uncertain-but-bounded parameters.
Sun, G, Luo, Z, Li, F, Zhang, N
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Efficient reliability-based optimization using a combined metamodel and FE-based strategy
, 2014 It is essential to consider the uncertainties in design variables of an optimization process in order to create a reliable design. The computational effort required to perform reliability-based optimization of complex engineering problems is very high ...
Shetty, Sandeep,
core
Metaheuristics and optimization in civil engineering
, 2016 This timely book deals with a current topic, i.e. the applications of metaheuristic algorithms, with a primary focus on optimization problems in civil engineering. The first chapter offers a concise overview of different kinds of metaheuristic algorithms,
Yang, Xin-She +2 more
core +1 more source