Results 31 to 40 of about 1,787,163 (286)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Increasing the robustness and crack resistivity of high-performance carbon fiber composites for space applications

iScience, 2021
Summary: The endeavors to develop manufacturing methods that can enhance polymer and composite structures in spacecraft have led to much research and innovation over many decades. However, the thermal stability, intrinsic material stress, and anisotropic
Michal Delkowski, Christopher T.G. Smith, José V. Anguita, S. Ravi P. Silva   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Students frequently ask: ‘Yes but...What is the utility of physics?’ [PDF]

, 2015
Two Teaching Innovation Projects were carried out in the framework of the subjects ‘Physics I’ and ‘Physics II’ for different Degrees on Engineering at the Engineering High School of the University of Cadiz, Spain, during the 2013-2014 course. The aim of
Cárdenas Leal, José Luis, García-Yeguas, Araceli, Gonzalez, Carlos, Muñoz Pérez, Juan José, Piñero de los Ríos, Manuel, Rosa Portillo, María Luisa de la, Vazquez, Agueda   +6 more
core   +1 more source

Physics in 100 Years

, 2015
Here I indulge in wide-ranging speculations on the shape of physics, and technology closely related to physics, over the next one hundred years.
Wilczek, Frank
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A self-powered and self-sensing knee negative energy harvester

iScience
Summary: Wearable devices realize health monitoring, information transmission, etc. In this study, the human-friendliness, adaptability, reliability, and economy (HARE) principle for designing human energy harvesters is first proposed and then a ...
Daning Hao, Yingjie Li, Jiaoyi Wu, Lei Zeng, Zutao Zhang, Hongyu Chen, Weizhen Liu   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigate the dynamic nature of soliton solutions and bifurcation analysis to a new generalized two-dimensional nonlinear wave equation with its stability

Results in Physics, 2023
In this current research, we investigate a new generalized two-dimensional nonlinear wave equation of engineering physics using two versatile approaches.
Asghar Ali, Jamshad Ahmad, Sara Javed, Shalan Alkarni, Nehad Ali Shah   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source