Results 41 to 50 of about 390,574 (312)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Dynamic analysis of a class of neutral delay model based on the Runge-Kutta algorithm
EURASIP Journal on Wireless Communications and Networking, 2018 In this paper, we study the dynamics of a class of second-order neutral delay nonlinear models. This study is applicable to many fields, such as engineering, cybernetics, and physics.
Hongying Luo
doaj +1 more source
Evaluating a Physics Engine as an Ingredient for Physical Reasoning [PDF]
, 2010 Physics engines have been used in robotics research for a long time. Beside their traditional application as a substitute for real world interactions due to their higher speed, safety and flexibility, they have recently also been used for motion planning and high level action planning. We propose to further explore the idea of using a physics engine as
Weitnauer, Erik +2 more
openaire +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effect of National Senior Certificate maths on the pass rate of first-year Engineering physics
South African Journal of Science, 2012 There has been much controversy about the mathematics results of the 2008 National Senior Certificate examinations - the first to be written by pupils following the outcomes-based curriculum.
Jagathesan Govender, Mervlyn Moodley
doaj
iScienceSummary: The existing infrared target simulation system with a total internal reflection (TIR) prism has the problem of low imaging contrast ratio, which will seriously affect the quality of the simulated image.
Zongyu Du +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source