Results 101 to 110 of about 2,141,178 (305)

Prefreshman and Cooperative Education Program [PDF]

Of the 93 students enrolled in the PREFACE program over its four-year history, 70 are still in engineering school. Tables show profiles of student placement and participation from 1973 to 1977 (first semester completed).

core   +1 more source

Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]

, 2010
William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Experiment on Flotation Energy Consumption of Coal Gasification Slag with Different Particle Fineness

Kuangchan zonghe liyong
Coal gasification slag is a solid by-product produced by the coal gasification process, which has certain utilization value but is difficult to complete separation.
Ruifeng CHEN, Danlong LI, Hainan WANG, Quanzhi TIAN, Haijun ZHANG   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cu Doping-Enabled Control of Grain Boundary Fusion and Particle Size in Single-Crystal LiNi_0.5Co_0.2Mn_0.3O₂ Cathode Materials

Batteries
Copper (Cu) doping is recognized as an effective strategy to enhance the electrochemical properties of LiNi1−x−yCoxMnyO2 (NCM) cathode materials. However, the influence of Cu2+ doping on particle size and grain boundary fusion remains insufficiently ...
Lang Xu, Zhipeng Wang, Ya Li, Jie Ding, Xiang Li, Ziqian Wang, Mingjiao Wu, Qiujian Zhang, Mingwu Xiang, Wei Bai, Fangkun Li, Yongshun Liang   +11 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing

International Journal of Nanomedicine
Xiaoyi Shi,1,* Jingqian Su,1,* Wenting Li,1 Keke Li,2 Xiangjun Chen,1 Wei Hong1 1School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, Yantai, Shandong ...
Shi X, Su J, Li W, Li K, Chen X, Hong W
doaj