Results 111 to 120 of about 2,141,178 (305)

Synthesis and Application of a Thermoplastic Plate of Poly(lactide-ε-caprolactone) for Radiation Therapy

Biomolecules, 2019
In this study, the poly(lactide-ε-caprolactone) (P(LA-CL)) copolymer is synthesized by ring-opening polymerization with glycol used as a molecular weight regulator to adjust the molecular weight of the polymer.
Hongli Li, Wenzhi Li, Hongtao Wu, Dengbang Jiang, Mingwei Yuan, Minglong Yuan   +5 more
doaj   +1 more source

Optomechanical cooling in a continuous system

, 2018
Radiation-pressure-induced optomechanical coupling permits exquisite control of micro- and mesoscopic mechanical oscillators. This ability to manipulate and even damp mechanical motion with light---a process known as dynamical backaction cooling---has ...
Behunin, Ryan O., Kittlaus, Eric A., Otterstrom, Nils T., Rakich, Peter T.   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Chiroptical switching and strong circularly polarized luminescence in peptide supramolecular assemblies

Nature Communications
Peptide-based materials offer unique advantages for constructing supramolecular chiral systems due to their bioactivity and intrinsic chirality. However, precise control over the expression, transfer, and amplification of chirality from the molecular to ...
Xin Li, Qingquan Han, Xianbao Li, Rui Li, Anhe Wang, Sen Liang, Yutao Sang, Jieling Li, Yajie Tian, Yang Yang, Qi Li, Shuo Bai, Junbai Li   +12 more
doaj   +1 more source

Bioinspired vine-wrapped PEEK/PAR nanocomposite paper with hierarchical interface coupling for enhanced dielectric strength and aging stability

Advanced Industrial and Engineering Polymer Research
This study presents a high-value green recycling strategy for waste polyetheretherketone (PEEK) to fabricate a bioinspired “vine-wrapping” nanocomposite insulating paper from recycled PEEK fibers and self-prepared polyarylate (PAR) nanofibers.
Hua Ma, Yuyan Hu, Han Ye, Qingquan Tang, Shiwen Yang, Hanwen Zhang, Luoxin Wang, Hua Wang, Siwei Xiong   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Information Literacy Instruction for Upper-Year Undergraduate Students: A Stratified Course-Integrated Approach [PDF]

, 2013
Undergraduate students face many potential barriers to learning about the process of conducting research. Information literacy instruction provided through faculty-librarian collaboration in an effort to expand the abilities of the “novice researcher ...
Nordlund, Stacey
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source