Results 131 to 140 of about 2,141,178 (305)

Di-(2-ethylhexyl) phthalate-degrading functional microorganisms were identified in black soil based on high throughput analysis

open access: yesCurrent Research in Microbial Sciences
Di-(2-ethylhexyl) phthalate (DEHP) has become an increasingly serious pollutant in soils. Microbial degradation represents a highly promising approach for its remediation.
Wenli Zhang   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

NASA Space Engineering Research Center for utilization of local planetary resources [PDF]

open access: yes
In 1987, responding to widespread concerns about both the health of American space technology development and the academic preparation of 21st-century space professionals, NASA announced a nationwide competition to establish a number of Space Engineering

core   +1 more source

The organization of the engineering site preparation

open access: yesBulletin of Prydniprovs’ka State Academy of Civil Engineering and Architecture, 2013
Пропонуються основні рішення організації інженерної підготовки будівельного майданчика з урахуванням функціональних ознак виконання робіт і систематизації однорідних ділянок по групах. Установлено залежності розподілу обсягу підготовчих робіт, дається зміна структури та обсягу робіт підготовчого періоду як функція щільності забудови.
Oleynik, P. І., Brodsky, V. I.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

PACE 2: Pricing and Cost Estimating Handbook [PDF]

open access: yes
An automatic data processing system to be used for the preparation of industrial engineering type manhour and material cost estimates has been established.
Shepherd, T., Stewart, R. D.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Space Station Furnace Facility. Volume 2: Requirements definition and conceptual design study [PDF]

open access: yes
The Space Station Freedom Furnace (SSFF) Project is divided into two phases: phase 1, a definition study phase, and phase 2, a design and development phase.

core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

PENERAPAN WORK PREPARATION DAN INTENSITAS PENDAMPINGAN PADA CAPAIAN PRESTASI PRAKTIK PEMESINAN MAHASISWA JURUSAN MESIN FAKULTAS TEKNIK UNIVERSITAS NEGERI YOGYAKARTA [PDF]

open access: yes
Work Preparation and Coaching Intensity to Improve Mechanical Engineering Students’ Academic Achievement in the Machinery Practicum in the Engineering Faculty of the Yogyakarta State University.
Th. Sukardi, Dr.
core  

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