Results 71 to 80 of about 2,073,600 (331)

Delivering manufacturing technology and workshop appreciation to engineering undergraduates using the flipped classroom approach [PDF]

, 2016
Delivery of manufacturing technology and practical workshop-based work, on undergraduate engineering courses that engage the learners, is challenging. The paper presents an experimental method of workshop delivery using the flipped learning approach, a ...
Anderson L, Biggs J, Bishop JA, Bryn H, DeGarmo, Euchner J, Kalpakjian S, Madhu GS, Richard AS, Richard HR, Vygotsky L   +10 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Understanding the New Civil Engineering Program Criteria: Preparing to Prepare the Future Civil Engineer [PDF]

2015 ASEE Annual Conference and Exposition Proceedings, 2015
Understanding the New Civil Engineering Program Criteria: Preparing to Prepare the Future Civil EngineerThe ASCE Civil Engineering Program Criteria Task Committee (CEPCTC) has completed itscharge to develop, in an open and inclusive manner seeking input from key stakeholder groups,and propose new Civil Engineering Program Criteria (CEPC).
Kenneth J. Fridley, Thomas A. Lenox , Dist.M.ASCE, F.ASEE   +1 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Preparation and Characterization of Bletilla striata Polysaccharide/Polylactic Acid Composite

Molecules, 2019
Polylactic acid (PLA) is limited in its application due to its high price, high brittleness and low glass-transition temperature. Modification methods are currently used to overcome these shortcomings. In this study, Bletilla striata polysaccharide (BSP)
Renyu Yang, Dongyue Wang, Hongli Li, Yi He, Xiangyu Zheng, Mingwei Yuan, Minglong Yuan   +6 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The crystal structure of tetrakis(imidazole)-copper(I) hexafluorophosphate, C12H16CuF6PN8

Zeitschrift für Kristallographie - New Crystal Structures, 2019
C12H16CuF6PN8, monoclinic, C2/c (no. 15), a = 13.102(2) Å, b = 9.7902(18) Å, c = 14.727(3) Å, β = 102.336(6)°, V = 1845.3(6) Å3, Z = 4, Rgt(F) = 0.0291, wRref(F2) = 0.0733, T = 150(2) K.
Zhong Wen-Wu, Tang Qian, Liu Ying-Jie, Shi Lei, Feng Yuan-Jiao, Tan Tao   +5 more
doaj   +1 more source

Preparation, In Vivo and In Vitro Release of Polyethylene Glycol Monomethyl Ether-Polymandelic Acid Microspheres Loaded Panax Notoginseng Saponins

Molecules, 2019
In order to enrich the types of Panax notoginseng saponins (PNS) sustained-release preparations and provide a new research idea for the research and development of traditional Chinese medicine sustained-release formulations, a series of Panax notoginseng
Yi He, Hongli Li, Xiangyu Zheng, Mingwei Yuan, Renyu Yang, Minglong Yuan, Cui Yang   +6 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source