Results 21 to 30 of about 477,954 (316)

NON-INVASIVE INVERSE PROBLEM IN CIVIL ENGINEERING

Acta Polytechnica CTU Proceedings, 2017
In this contribution we focus on recovery of spatial distribution of material parameters utilizing only non-invasive boundary measurements. Such methods has gained its importance as imaging techniques in medicine, geophysics or archaeology.
Jan Havelka, Jan Sýkora, Anna Kučerová   +2 more
doaj   +1 more source

Black-Winged Kite Algorithm Integrating Opposition-Based Learning and Quasi-Newton Strategy

Biomimetics
To address the deficiencies in global search capability and population diversity decline of the black-winged kite algorithm (BKA), this paper proposes an enhanced black-winged kite algorithm integrating opposition-based learning and quasi-Newton strategy
Ning Zhao, Tinghua Wang, Yating Zhu
doaj   +1 more source

Fifty Years on: A Retrospective on the World's First Problem-based Learning Programme at McMaster University Medical School

Health Professions Education, 2019
There are many false ideas and a prioris about the history of problem-based learning in medical education, stemming from a dearth of historical studies of PBL. This study was conducted at McMaster University Faculty of Health Sciences and offers rigorous
Virginie F.C. Servant-Miklos
doaj   +1 more source

The Harvard Connection: How the Case Method Spawned Problem-Based Learning at McMaster University

Health Professions Education, 2019
This paper proposes a historical analysis of the connection and differences between the Harvard case method in medical education and business education and the original problem-based learning method of McMaster University as it was developed in the late ...
Virginie F.C. Servant-Miklos
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Problem-based teaching in engineering education

MATEC Web of Conferences, 2016
The aerospace industry requires highly educated, motivated engineers capable of working with increasingly complex processes and equipment, rapidly-changing requirements, and the need to constantly improve production efficiency.
Kuimova Marina, Burleigh Douglas, Trofimova Anastasiya   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Is It Problem or Project-Based Instruction: Implementing PBI for the First Time in an Engineering Mechanics College Course

Education Sciences, 2023
This mixed methods study investigated a college engineering professor’s first-time implementation of project/problem-based instruction (PBI) within an engineering mechanics (EM) course and compared this implementation with a business-as-usual (BAU) EM ...
Jennifer Anne Daddysman, Jennifer Anne Wilhelm, Farzad Taghaddosi   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source