Results 41 to 50 of about 1,110,977 (259)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Processing of nanostructured nickel-based magnetic materials

open access: yes, 2006
A systematic investigation into the structure and properties of five commercially available nickel-based soft magnetic materials was carried out. The five systems are Fe23Ni77, Fei6Ni77Cu7, Fei6Ni77Cu5Cr2, Fei6Ni77Mo7 and Fei6Ni77Nb7.
School of Materials Science and Engineering
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Materials Science and Engineering Baccalaureate Degree Annual Program Outcomes Assessments, 2022-23 [PDF]

open access: yes, 2023
This report reviews Wright State University\u27s Materials Science and Engineering Baccalaureate Degree program for the 2022-2023 academic ...
College of Engineering and Computer Science, Wright State University
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Mass transfer modeling of DRI particle-slag heat transfer in the electric furnace. [PDF]

open access: yes, 1979
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1979.MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.Includes bibliographical references.M ...
Wright, Randall Stephen
core  

The influence of position in overlap joints of Mg and Al alloys on microstructure and hardness of laser welds [PDF]

open access: yes, 2013
Structure and properties of laser beam welding zone of dissimilar materials, AZ31 magnesium alloy and A5754 Aluminum alloy, are investigated. The microstructure and quality of the Mg/Al weld were studied by metallography, microhardness and optical ...
BANNOUR, Sana   +11 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The World of Materials, Fall 1998

open access: yes, 1998
This is the biannual newsletter for the Department of Materials Science and ...

core  

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