Results 131 to 140 of about 1,482,915 (314)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

International Conference on Computational & Experimental Engineering and Sciences

open access: yes
The Journal is intended to publish the selected paper from the conference ICCES (http://www.icces.org), for the worldwide free distribution. The conference ICCES is to bring researchers from the world's acdemia, industry, and the governments to discuss ...
Demosthenes Polyzos   +22 more
core  

10th International Conference on Biosystems Engineering 2019 : Book of Abstracts : May 8-10 2019 in Tartu, Estonia

open access: yes, 2019
Full textBook of Abstracts. 10th International Conference on Biosystems Engineering 2019, May 8–10, 2019 Tartu, Estonia.
Estonian University of Life Sciences
core  

Graphene : recent advances in engineering, medical and biological sciences, and future prospective

open access: yes, 2018
Graphene, a two dimensional carbon allotrope, has been appeared as an interesting material of the 21st century, and received world-wide attention due to its extraordinary thermal, optical, and mechanical properties. Graphene and its derivatives are being
Gholami, Ahmad   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Human dorsal forebrain organoids show differentiation-state-specific protein secretion

open access: yesiScience
Summary: The human brain microenvironment undergoes dynamic changes during development, which have been incompletely characterized in in vitro models including neural organoids.
Zeynep Yentür   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Engineering and Physical Sciences Research Council (EPSRC)

open access: yes
The Engineering and Physical Sciences Research Council (EPSRC) funds research and training in the UK in engineering and the physical sciences. Viewing public engagement as important for stimulating interest in research, inspiring future generations of ...

core  

Gender representation and experiences of gender bias in coastal geoscience and engineering

open access: yes
This dataverse contains data on gender representation and experiences of gender bias in coastal geoscience and engineering in 2016. This includes data of gender representation on journal editorial boards, societies, and conference organisation committees.
Women in Coastal Geoscience and Engineering
core   +2 more sources

Emerging Agricultural Engineering Sciences, Technologies, and Applications

open access: yesAgriEngineering
The closing Editorial of this comprehensive special collection presents the journey from this project’s inception to the publication of around five dozen outstanding studies that have been a testament to the dedication, innovation, and collective wisdom ...
Muhammad Sultan
doaj   +1 more source

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