Results 111 to 120 of about 3,645,822 (281)
Research Laboratory of Electronics Quarterly progress report, period ending 28 Feb. 1967 [PDF]
General physics, plasma dynamics, engineering, and communication sciences programs at Research Laboratory of ...
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
40 years IUPESM: The International Union for Physical and Engineering Sciences in Medicine. [PDF]
Health Technol (Berl), 2020 Goh JC, Tabakov SD.
europepmc +1 more source
On the Difference between Assumption-Based Argumentation and Abstract Argumentation [PDF]
, 2015 Acknowledgements The first author has been supported by the National Research Fund, Luxembourg (LAAMI project) and by the Engineering and Physical Sciences Research Council (EPSRC, UK), grant ref. EP/J012084/1 (SAsSy project).
Alcântara, João +3 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A 3D tumor spheroid model with robust T cell infiltration for evaluating immune cell engagers
iScienceSummary: A strong interest in drugs targeting the tumor microenvironment (TME) necessitates new experimental systems that incorporate key TME components.
Hin Ching Lo +10 more
doaj +1 more source
"Triples" for information research skills : a multi-disciplinary approach [PDF]
, 2011 This paper outlines a new approach to teaching reference/research skills. It was developed for PhD students but has been used successfully for teaching reference and search skills to students on a Masters in Library and Information Studies.
Poulter, Alan
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