Results 111 to 120 of about 1,482,915 (314)

Research and Science Today No. 2(8)/2014 [PDF]

Research and Science Today, 2014
RESEARCH AND SCIENCE TODAY is a biannual science journal established in 2011. The journal is an informational platform that publishes assessment articles and the results of various scientific research carried out by academics.
Cătălin TECUCIANU, Crucița-Loredana BACIU, Elena-Steluţa DINU, Teodora DOBRE, Emilia - Elena CLUCERESCU (TĂNASE), Filip NALASKOWSKI, Andreea Emilia DUŢĂ, Ion PANAIT, Paul DUŢĂ, Flavius-Cristian MĂRCĂU, Silvian-Emanuel MAN, Răzvan MUNTEANU, Crina SOROIU, Diana Catalina CAZANGIU, Natalia FURTUNA, Nicolae (MĂNESCU) RALUCA, Nedelcu ANIŞOR, Traian Eugen BOLFA, Iulia BOGHIRNEA, Ion Cristinel RUJAN, Dana VULPAȘU, Dagna DEJNA, Elena BRAN, Nicolaie MĂNESCU, Marin AURELIA CAMELIA, Voicu TATIANA, Răzvan BRAN, Raul Constantin TĂNASE, Cosmin CIORA , Mircea DICULESCU, Raluca Ioana TELEANU, Magdalena SANDU , Daniel Mihai TELEANU, Smaranda NIȚĂ, Dan Vasile POP, Marius TEODORESCU, Daniela RADU, Iulia SAVU   +37 more
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

University of Central Florida 1985 Self Study Southern Association of Colleges and Schools: Department of Mechanical Engineering and Aerospace Sciences Self Study

, 1985
University of Central Florida Mechanical Engineering and Aerospace Sciences 1985 Self Study for Southern Association of Colleges and Schools. The study covers philosophy of the university and the college, organizational structure, educational program ...
University of Central Florida. Mechanical Engineering and Aerospace Sciences
core  

40 years IUPESM: The International Union for Physical and Engineering Sciences in Medicine. [PDF]

Health Technol (Berl), 2020
Goh JC, Tabakov SD.
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source