Results 101 to 110 of about 1,590,550 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Gateway to the World: Jewish and Armenian Engineers of Ottoman Background at the École centrale des arts et manufactures (1853-1923)

Diasporas: Circulations, Migrations, Histoire, 2017
In the second half of the 19th century, the French École centrale des arts et manufactures became one of the engineering schools that enjoyed a worldwide reputation. There were many foreigners among its students.
Darina Martykánová
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Students Engineer Solution to Public Health Issue in Dominican Republic [PDF]

, 2016
Student chapter of Engineers Without Borders dispatches to rural village to build invention that replaces open-fire ...
Rodrigues, Jill
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Professional-applied physical training of future specialists in the oil and gas industry with the predominant use of the game method

Physical Education of Students
Background and Study Aim. Physical training plays a crucial role in preparing future specialists for the demands of the oil and gas industry, where physical endurance and coordination are essential for professional activities.
Roman Boichuk, Oleh Vintonyak, Volodymyr Kryzhanivskyi, Roman Mikhailenko, Andriy Shankovskyi, Ihor Belyavskyi, Andriy Hrabchuk   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 14: An analysis of the technical communications practices reported by Israeli and US aerospace engineers and scientists [PDF]

As part of Phase 4 of the NASA/DoD Aerospace Knowledge Diffusion Research Project, two pilot studies were conducted that investigated the technical communications practices of Israeli and U.S. aerospace engineers and scientists. Both studies had the same
Barclay, Rebecca O., Elazar, David, Kennedy, John M., Pinelli, Thomas E.   +3 more
core   +1 more source

Freehand Sketching for Engineers: A Pilot Study [PDF]

, 2013
This paper describes a pilot study to evaluate Freehand Sketching for Engineers, a one credit, five week course taught to undergraduate engineering students.
Goldberg, Jay R., Marklin, Richard W., Jr., Nagurka, Mark L.   +2 more
core   +1 more source