Results 51 to 60 of about 1,596,446 (317)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The mathematical components of engineering expertise: the relationship between doing and understanding mathematics [PDF]
, 2002 this paper are extracts from our interviews with engineers.) Where, then, is the complex mathematics that certainly exists in modern engineering? Throughout all aspects of engineering design, computer software has an overwhelming presence.
Kent, Phillip, Noss, Richard
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Aging engineers’ occupational self-efficacy—a mixed methods study
Frontiers in Psychology, 2023 IntroductionEngineers’ work has become more complex with increased demands in today’s changing working life. Self-efficacy is essential to successfully adapt to work-related changes and to cope with adverse job demands. However, less is known about aging
Stina Wallin +3 more
doaj +1 more source
Mindful Engineers in Sustainable Engineering
IEEE Technology and Society Magazine, 2019 According to the Encyclopadia Britannica, the establishment of the Royal Society of London for Improving Natural Knowledge (Royal Society), the "oldest national scientific society in the world," was on November 28, 1660. In 1818, the Institution of Civil Engineers (ICE), the first professional engineering body, was also set up in London.
Basart i Muñoz, Josep M. +2 more
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Readers, readers, writers and engineers [PDF]
, 2005 Extended review of books <i>Knowledge, Power and Learning</i> and <i>Learning, Space and Identity</i>, both ed. Carrie Paechter et al., Paul Chapman Publishing (2001).
Gray, N.
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Skills in Ethics for Engineers [PDF]
, 2006 A script of a lecture giving examples of everyday ethical statements made in an engineering context, making a link with the views of the ethicist G.E.
Monk, John
core