Results 171 to 180 of about 1,080,903 (314)

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

open access: yesAdvanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie   +21 more
wiley   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

open access: yesAdvanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie   +9 more
wiley   +1 more source

Predictable Self‐Assembly as an Unexplored Key Factor Influencing Membrane Separation: Insights from Monophenols

open access: yesAdvanced Science, EarlyView.
Predictable molecular self‐assembly strength is key to membrane separation, contrary to typical understanding. Monophenol research shows substituent abundance and specificity govern self‐assembly strength. This predictability enables a novel separation method: membranes reject molecules with stronger self‐assembly more effectively, separating similarly
Qiuyu Han   +10 more
wiley   +1 more source

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

open access: yesAdvanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li   +20 more
wiley   +1 more source

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