Results 201 to 210 of about 4,806,683 (407)

TES: A modular systems approach to expert system development for real-time space applications [PDF]

A major goal of the Space Station era is to reduce reliance on support from ground based experts. The development of software programs using expert systems technology is one means of reaching this goal without requiring crew members to become intimately ...
Cacace, Ralph, England, Brenda
core   +1 more source

Builders’ wages in southern England and the southern Low Countries, 1346 -1500: a comparative study of trends in and levels of real incomes [PDF]

, 2004
John H. Munro
openalex  

Funding and performance of healthcare systems in the four countries of the UK before and after devolution: a longitudinal analysis of the four countries, 1996/97, 2002/03 and 2006/07, supplemented by cross-sectional regional analysis of England, 2006/07 [PDF]

, 2011
Sheelah Connolly, Gwyn Bevan, Nicholas Mays   +2 more
openalex   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Diverse genomic landscape of swine influenza A virus in England (2014-2021). [PDF]

Microb Genom
Mollett BC, Byrne AM, Everett HE, Reid SM, Williamson S, Anderson TK, James J, Banyard AC, Brown IH, Lewis NS.   +9 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Disparities in blood cancer survival in the UK 2009-2019: national cohort studies. [PDF]

BJC Rep
Hoang J, Allen J, Capel R, Thomas R, Smits S, Ahmed R, Webb H, Sheikh A, Cox S, Bygrave C, Hippisley-Cox J.   +10 more
europepmc   +1 more source

Coping with the Unknown: Scribes and the Transmission of Scientific Texts in Late Medieval England (York, York Minster Chapter Library, MS. XVI E. 32: a Case Study)

Rebeca Cubas-Peña
openalex   +1 more source

Field-faring women: the resistance of women who worked in the fields of nineteenth-century England [PDF]

, 1993
Karen Sayer
openalex   +1 more source