Results 241 to 250 of about 4,724,242 (392)

Awareness and use of oral nicotine pouches among youth and young adults, 2022-2024: repeat cross-sectional surveys in Canada, England, the USA and New Zealand. [PDF]

open access: yesBMJ Public Health
Reid JL   +9 more
europepmc   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

open access: yesAdvanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan   +7 more
wiley   +1 more source

A novel approach for mapping exposure to land cover at the small statistical geography level. [PDF]

open access: yesInt J Health Geogr
Garrett JK   +7 more
europepmc   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

open access: yesAdvanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang   +9 more
wiley   +1 more source

ENGLAND: March and April were the Cruellest Months

open access: yesCritical Stages, 2020
John Causebrook, John Elsom
doaj  

Ear and mastoid process-related hospital admissions in England and Wales: A descriptive ecological study. [PDF]

open access: yesMedicine (Baltimore)
Alsairafi ZK   +5 more
europepmc   +1 more source

Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study

open access: yesBritish medical journal, 2006
Mary C M Macintosh   +7 more
semanticscholar   +1 more source

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

open access: yesAdvanced Science, EarlyView.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani   +20 more
wiley   +1 more source

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