Results 241 to 250 of about 4,282,224 (344)

The Origin of the English Common Law and the Treatise on the Laws and Customs of the Kingdom of England

, 2019
Vsevolod F. Baranov
openalex   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Notes in England and Italy

, 1870
Sophia Peabody Hawthorne
openalex   +1 more source

The Particularities of the Legal Status and Liability of the Parties of the Contractual Relations within the Sphere of Tourism in England

, 2016
Полина Сергеевна Барабанова
openalex   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

How does mortality compare between different countries/regions of birth for the population of England and Wales, 2007 to 2021? A descriptive, observational study. [PDF]

J R Soc Med
Hiam L, Minton J, Burns R, Aldridge RW.
europepmc   +1 more source

A taxonomy of iguanodontians (Dinosauria: Ornithopoda) from the lower Wealden Group (Cretaceous: Valanginian) of southern England

, 2010
David Norman
openalex   +1 more source

Hydrogel‐Coated Foam Evaporator Achieving Four‐In‐One Benefits for Efficient and Stable Solar‐Driven Water Purification

Advanced Science, EarlyView.
This study introduces a universal strategy for foam‐based solar evaporators, leveraging the unique advantages of hydrogel materials to effectively reduce evaporation enthalpy. At the same time, it addresses challenges such as the need for pore formation in hydrogels, water‐induced swelling, and the detachment of photothermal materials, achieving “four ...
Lele Li, Yanhong Dong, Shu Liu, Xingmin Du, Diandian Yu, Jie Wen, Chenxi Wang, Qian Sun, Bing Liu, Tao Wu, Jiahui Yu   +10 more
wiley   +1 more source

Core Mental Health Data Set (CMHDS) methods feasibility paper. [PDF]

BMJ Health Care Inform
Abel KM, Edwardes A, Tranter H, Dark P, Sandler RD, Kalra PA, John A, Wildman M, Bell P, Bakerly ND, Whelan P.   +10 more
europepmc   +1 more source