Results 241 to 250 of about 4,806,683 (407)

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Referral to treatment times in the National Health Service of England: A five-year analysis of the impact of the COVID-19 Pandemic and socioeconomic deprivation and future implications for Ear, Nose and Throat service delivery. [PDF]

PLoS One
Spinos D, Beech T, Lee J, Coulson C, French L, Greenfield S, Litchfield I, Nankivell P, Allen R, Muzaffar J.   +9 more
europepmc   +1 more source

Earthing common worship: an ecotheological critique of the Common Worship texts of the Church of England [PDF]

, 2011
Jeremy Mark Sebastian Clines
openalex  

Different approaches to regulations: Moving to non-statutory guidance for farming animal welfare codes in England [PDF]

, 2016
S Wickens
openalex   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Primary care's role in <i>The National Cancer Plan for England</i>. [PDF]

Br J Gen Pract
Merriel S.
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial. [PDF]

BMJ Open
Laycock K, Kearney J, Lee YN, Macfarlane J, Goodchild E, Ng E, Pineau Mitchell A, Wu X, Htut Z, Goodchild G, Lowe D, Hilliard N, Godfrey E, Qazi N, Bastos J, Chua A, Mahroof R, Palma A, Khatun A, Varsani C, Benu D, Pereira SP, Krishnamurthy M, Cheow H, Chung TT, Carroll P, O'Toole S, Wernig F, Gurnell M, Brown M, Drake WM.   +30 more
europepmc   +1 more source

Facilitative and competitive interaction components among New England salt marsh plants

, 2017
John F. Bruno, Tatyana A. Rand, Nancy C. Emery, Mark D. Bertness   +3 more
openalex   +1 more source

Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study

British medical journal, 2006
M. Macintosh, K. Fleming, J. A. Bailey, Pat Doyle, J. Modder, Dominique Acolet, Shona Golightly, Alison Miller   +7 more
semanticscholar   +1 more source