Results 261 to 270 of about 4,724,242 (392)

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K. [PDF]

Euro Surveill
Kirsebom FC, Thompson C, Talts T, Kele B, Whitaker HJ, Andrews N, Abdul Aziz N, Rawlinson C, Green RE, Quinot C, Gardner N, Waller E, Allen A, Watson CH, McDonald SL, Zambon M, Pebody R, Ramsay M, Hoschler K, Singanayagam A, Lopez Bernal J.   +20 more
europepmc   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Exploring barriers to expanding medical training numbers in England: A national survey of medical education directors. [PDF]

Clin Med (Lond)
Batavanis M, Arora A, Aryee S, Nathwani N.   +3 more
europepmc   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Mortality in people with intellectual disabilities in England

Journal of Intellectual Disability Research, 2017
Gyles Glover, Rachael Williams, Pauline Heslop, J. Oyinlola, Jillian Grey   +4 more
semanticscholar   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

The impact of the COVID-19 pandemic on the rate of maternal postnatal healthcare examinations in England: an OpenSAFELY interrupted time series analysis providing evidence of disparity in care access. [PDF]

BMC Med
Hayes DJL, Schaffer AL, Mehrkar A, Bacon SCJ, Goldacre B, MacKenna B, Heazell AEP, van Staa T, Palin V.   +8 more
europepmc   +1 more source

GP commissioning in England

, 2013
Rodger Charlton
openalex   +2 more sources

Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2

British medical journal, 2008
J. Hippisley-Cox, C. Coupland, Y. Vinogradova, John Robson, Rubin Minhas, Aziz Sheikh, P. Brindle   +6 more
semanticscholar   +1 more source