Results 31 to 40 of about 4,282,224 (344)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Residential child care in England
Scottish Journal of Residential Child Care, 2016 This article provides a summary of the current context for residential child care in England. It records continually increasing outcomes as evidenced in a new set of Quality Standards by a new inspection framework.
Jonathan Stanley
doaj +1 more source
Formulating problems for real algebraic geometry [PDF]
, 2014 We discuss issues of problem formulation for algorithms in real algebraic geometry, focussing on quantifier elimination by cylindrical algebraic decomposition.
England, Matthew
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
All Wired Up and Ready to Go [PDF]
, 2002 The School of Law\u27s new facility is one of the most technologically advanced legal education buildings in the country.
England, Marlene
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Ageing of convicted prisoners: some problems and solutions (domestic and comparativistic aspects)
Правоприменение, 2023 The subject of the article is the peculiarities of the execution of imprisonment in relation to the elderly (over 50 years old) as an independent legal institution of penitentiary law in Russia and abroad.The purpose of the article is to identify the ...
P. V. Teplyashin +2 more
doaj +1 more source
An implementation of Sub-CAD in Maple [PDF]
, 2015 Cylindrical algebraic decomposition (CAD) is an important tool for the investigation of semi-algebraic sets, with applications in algebraic geometry and beyond.
England, Matthew, Wilson, David
core +3 more sources
The relationship between civic attitudes and voting intention : an analysis of vocational upper secondary schools in England and Singapore [PDF]
, 2013 From 2009 to 2011, a team from the Centre for Learning and Life Chances in Knowledge Economies and Societies carried out a mixedmethods study of young people in England and Singapore.
Han, Christine +2 more
core +3 more sources