Results 31 to 40 of about 1,080,903 (314)

England, whose England?

Early Modern Culture Online, 1987
A review essay of Adriana Neagu, Continental Perceptions of Englishness, ‘Foreignness’ and the Global Turn. Newcastle-upon-Tyne: Cambridge Scholars, 2017.
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Some patterns of the ‘Murdered Sweetheart Ballads’ in oral tradition, early recordings, and popular culture. [PDF]

Studia Ethnologica Pragensia, 2023
Narrative songs with regards to the theme called ‘murdered sweetheart”, are part of a wider repertoire of murder ballads that circulated in England, Scotland, Ireland, and North America. It is through these Murdered Sweetheart Ballads (cf.
Delia Dattilo
doaj  

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

İngiltere’de İslam Eğitimi: Fırsatlar ve Tehditler

Cumhuriyet İlahiyat Dergisi, 2020
Araştırmamızda İngiltere’de Müslüman ailelerin, çocuklarına din eğitimi aldırma imkânlarının ne olduğunun araştırılması ve İslam eğitimi verilen kurum ya da yapıların incelenmesi amaçlanmıştır. Doküman incelemesi yöntemi benimsenen çalışmamızda, konu ile
İrfan Erdoğan
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Geoffrey of Monmouth and Breton aristocracy in 12th century England: Social and political contexts of “On the deeds of the Britons”

Шаги, 2023
The article is devoted to reconstructing the social context of the works of Geoffrey of Monmouth, one of the most prominent 12th-century English historical writers.
S. G. Mereminskiy
doaj   +1 more source

Hamlet in England [PDF]

The Journal of the Sylvia Townsend Warner Society, 2021
An unpublished short story by Sylvia Townsend Warner. It fancifully elaborates the story of Acts 4 and 5 of Hamlet, starting on board the ship taking Hamlet to England after the killing of Polonius. The story begins before the Danish vessel’s encounter with a pirate ship and Hamlet’s capture by the pirates, and imagines the circumstances by which he ...
openaire   +4 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source