Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Book review: Behind Closed Doors: Why We Break Up Families - and How to Mend Them by Polly Curtis
Scottish Journal of Residential Child Care, 2022 When approaching this book review, I initially started to write a 'classic' review in the time-honoured tradition that includes all the usual components.
David Anderson
doaj +1 more source
Social distancing, population density, and spread of COVID-19 in England: a longitudinal study
BJGP Open, 2020 Background: The UK government introduced social distancing measures between 16–22 March 2020, aiming to slow down transmission of COVID-19. Aim: To explore the spreading of COVID-19 in relation to population density after the introduction of social ...
Peter Tammes
doaj +1 more source
English Financiers of the Middle of the XIV Century: Features and Results of Activity
Научный диалог, 2021 The article examines the features of the country’s economic and political development in the second third of the XIV century through the prism of analyzing the activities of famous representatives of the commercial and financial stratum of England.
O. V. Yablonskaya
doaj +1 more source
Design of conditions for emergence of self-replicators
, 2018 A self-replicator is usually understood to be an object of definite form that promotes the conversion of materials in its environment into a nearly identical copy of itself.
England, Jeremy L., Sarkar, Sumantra
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT
Health Technology Assessment, 2018 Background: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment.
Robert Howard +25 more
doaj +1 more source
Assessment in vocational programmes in the further education sector in England: report from the Inspectorate (National survey report, January 1995) [PDF]
, 1995 This national survey report is concerned with the assessment of students attending all types of vocational education and training programmes offered by further education sector colleges in England.
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source