Results 71 to 80 of about 4,724,242 (392)
BMJ Open, 2020 Objective To estimate the health and financial burden of adverse childhood experiences (ACEs) in England and Wales. Design The study combined data from five randomly stratified cross-sectional ACE studies.
K. Hughes +4 more
semanticscholar +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
"Elementary, my dear Watson". Per una falsa citazione [PDF]
Parole Rubate, 2014 Nowhere, among Sir Arthur Conan Doyle's pages concerning one of the most celebrated characters of British literature, Sherlock Holmes, is to be found the interjection: "Elementary, my dear Watson!".
Irene Minella
doaj
The origins of casual culture: hooliganism and fashion in Great Britain
Culture & History Digital Journal, 2019 This dissertation attends to the study of football hooligans’ subcultures. In particular, it addresses a general synthesis of the beginnings of casual culture in Great Britain, within the context of the cultural transition process of the 1980s, and ...
César Rodríguez Blanco
doaj +1 more source
Social distancing, population density, and spread of COVID-19 in England: a longitudinal study
BJGP Open, 2020 Background: The UK government introduced social distancing measures between 16–22 March 2020, aiming to slow down transmission of COVID-19. Aim: To explore the spreading of COVID-19 in relation to population density after the introduction of social ...
Peter Tammes
doaj +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
Can a profession exist without research? [PDF]
, 2019 Radiography combines science, technology and patient care to provide an essential role in medical diagnosis and treatment. The term ‘profession’ has existed in the Oxford English Dictionary from the 15th century and argues that a profession is an ...
England, A, Ogenyi, A, Robertson, S
core +3 more sources
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Modelling non-stationary flood frequency in England and Wales using physical covariates
Hydrology ResearchNon-stationary methods of flood frequency analysis are widespread in research but rarely implemented by practitioners. One reason may be that research papers on non-stationary statistical models tend to focus on model fitting rather than extracting the ...
Duncan S. Faulkner +3 more
doaj +1 more source