Results 61 to 70 of about 5,339,744 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of Fin Efficiency and Heat Transfer Coefficient for Fined Tube Heat Exchange [PDF]

, 2012
This study discussed the estimation of the fin efficiency and the pure-heat transfer coefficient in the heat exchanger. One hundred twenty cases of plate fins having known heat transfer coefficients were tested numerically to investigate the validity of ...
Kang, Hiechan
core   +1 more source

Preparation and Thermal Model of Tetradecane/Expanded Graphite and A Spiral Wavy Plate Cold Storage Tank

Energies, 2022
A cold storage unit can store the cold energy off-peak and release it for building cooling on-peak, which can reduce the electricity load of air conditioning systems.
Hongguang Zhang, Tanghan Wu, Lei Tang, Ziye Ling, Zhengguo Zhang, Xiaoming Fang   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Review of convective heat transfer enhancement with nanofluids

International Journal of Heat and Mass Transfer, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kakac, Sadik, Pramuanjaroenkij, Anchasa
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Performance comparison of liquid, vapor, and liquid–vapor injection of single-screw compressor for an air-source heat pump

AIP Advances
Refrigerant injection techniques are usually proposed to improve the performance and reliability of compressors when a single-screw compressor applied to an air-source heat pump works at low temperatures in winter.
Qiangyu Wen, Ruiping Zhi, Yuting Wu, Biao Lei, Yanjun Du   +4 more
doaj   +1 more source

Performance Analysis and Rapid Optimization of Vehicle ORC Systems Based on Numerical Simulation and Machine Learning

Energies
The organic Rankine cycle (ORC) system is an important technology for recovering energy from the waste heat of internal combustion engines, which is of significant importance for the improvement of fuel utilization. This study analyses the performance of
Xin Wang, Xia Chen, Chengda Xing, Xu Ping, Hongguang Zhang, Fubin Yang   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Electromagnetic enhancement of turbulent heat transfer

Physical Review E, 2008
We performed large eddy simulations (LES) of the turbulent natural convection of an electrically conductive fluid (water with 7% Na2SO4 electrolyte solution) in a moderate (4:4:1) aspect ratio enclosure heated from below and cooled from above and subjected to external nonuniformly distributed electromagnetic fields.
openaire   +4 more sources