Results 81 to 90 of about 5,339,744 (294)
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Tables for solution of the heat-conduction equation with a time-dependent heating rate [PDF]
, 1962 Tables are presented for the solution of the transient onedimensional heat flow in a solid body of constant material properties with the heating rate at one boundary dependent on time. These tables allow convenient and rapid estimation of the temperature
Bergles A. E.
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Heat transfer to impacting drops and post critical heat flux dispersed flow
, 1978 Heat transfer to drops impacting on a hot surface is examined in context of dispersions of flowing, boiling fluids. The liquid contribution to heat transfer from a hot tube to a two-phase dispersion is formulated in terms of heat transfer contributions ...
Kendall, Gail E., Rohsenow, Warren M.
core
Dual-Mode Wicking Structures for Enhanced Evaporative Heat Transfer [PDF]
, 2012 This paper reports on conceptual design and thermo-fluid characteristics of two-phase flow devices enabled by dualmode wicks. In dual-mode wicking structures, liquid and vapor flow paths are integrated on the same plane and segregated flow of the two ...
TeGrotenhuis, Ward E, Krishnan, Shankar
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Inorganic Salt Hydrate for Thermal Energy Storage
Applied Sciences, 2017 Using phase change materials (PCMs) for thermal energy storage has always been a hot topic within the research community due to their excellent performance on energy conservation such as energy efficiency in buildings, solar domestic hot water systems ...
Ning Xie +5 more
doaj +1 more source
, 2020 The laminar and turbulent regimes of a boundary layer on a flat plate are often represented with separate correlations under the assumption of a distinct “transition Reynolds number.” Average heat coefficients are then calculated by integrating across ...
Lienhard, John H, Lienhard, John H.
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source