Results 101 to 110 of about 1,268,330 (308)

mSphere of Influence: Metabolic redundancies enhance pathogenesis

mSphere
ABSTRACT McKenzie Lehman works in the field of bacterial pathogenesis and metabolism. In this mSphere of Influence article, she reflects on how three papers entitled “Glycolytic dependency of high-level nitric oxide resistance and virulence in Staphylococcus aureus” by N. P.
openaire   +3 more sources

RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders

Peptides, 2018
There is a marked increase in the incidence of visceral adiposity and insulin resistance among women following menopause. Adrenomedullin (AM) is an endogenous peptide first identified as a vasodilator, but now known to exert a variety of physiological effects.
Teng, Liu, Akiko, Kamiyoshi, Megumu, Tanaka, Shiho, Iida, Takayuki, Sakurai, Yuka, Ichikawa-Shindo, Hisaka, Kawate, Kazutaka, Hirabayashi, Kun, Dai, Nanqi, Cui, Masaaki, Tanaka, Yangxuan, Wei, Keisei, Nakamura, Shuhei, Matsui, Akihiro, Yamauchi, Takayuki, Shindo   +15 more
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ALS gene overexpression and enhanced metabolism conferring Digitaria sanguinalis resistance to nicosulfuron in China. [PDF]

Front Plant Sci, 2023
Wang R, Sun Y, Lan Y, Wei S, Huang H, Li X, Huang Z.   +6 more
europepmc   +1 more source

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. [PDF]

, 2017
G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Aryal, Dipendra K., Benovic, Jeffrey L., Luo, Jiansong, Nass, Richard, Wang, Jianjun, Wetsel, William C.   +5 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Multi-frequency electromagnetic radiation promoted hepatic lipid metabolism via the adiponectin pathway in mice

Ecotoxicology and Environmental Safety
Radiofrequency electromagnetic radiation (RF-EMR) is ubiquitous in daily life, and the complexity of the electromagnetic environment continues to increase. Nevertheless, research on the biological effects of compound radiofrequency radiation—particularly
Jing Xu, Xinyu Wang, Menghua Li, Lihui Zhang, Xuelong Zhao, Guofu Dong, Changzhen Wang   +6 more
doaj   +1 more source

The Photorespiratory BOU Gene Mutation Alters Sulfur Assimilation and Its Crosstalk With Carbon and Nitrogen Metabolism in Arabidopsis thaliana

Frontiers in Plant Science, 2018
This study was aimed at elucidating the significance of photorespiratory serine (Ser) production for cysteine (Cys) biosynthesis. For this purpose, sulfur (S) metabolism and its crosstalk with nitrogen (N) and carbon (C) metabolism were analyzed in ...
Sladjana Samuilov, Dominik Brilhaus, Nadine Rademacher, Samantha Flachbart, Leila Arab, Saleh Alfarraj, Franziska Kuhnert, Stanislav Kopriva, Andreas P. M. Weber, Tabea Mettler-Altmann, Heinz Rennenberg, Heinz Rennenberg   +11 more
doaj   +1 more source

Cytochrome P450s-Involved Enhanced Metabolism Contributes to the High Level of Nicosulfuron Resistance in Digitaria sanguinalis from China. [PDF]

Biology (Basel), 2023
Wang X, Hu W, Li Y, Jiang M, Zhao N, Cao H, Liao M.   +6 more
europepmc   +1 more source

Metabolic Dependencies in Pancreatic Cancer. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R., Vaziri-Gohar, Ali, Winter, Jordan M., Zarei, Mahsa   +3 more
core   +1 more source