Results 121 to 130 of about 4,699,722 (297)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Online Personal Data Processing and EU Data Protection Reform. CEPS Task Force Report, April 2013 [PDF]

, 2013
This report sheds light on the fundamental questions and underlying tensions between current policy objectives, compliance strategies and global trends in online personal data processing, assessing the existing and future framework in terms of effective ...
Luchetta, Giacomo, Irion, Kristina
core  

MEC Placement Problem in Protected 5G Networks

CLEI Electronic Journal
This paper summarizes the thesis ”MEC Placement Problem in Protected 5G Networks”, which tackles the question of where to position Multi-access edge computing nodes (MECs) in 5G networks to achieve stringent 5G requirements at a minimum cost. The thesis
Hernani Delgado Chantre
doaj   +1 more source

Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice. [PDF]

Microbiol Spectr, 2021
Piergallini TJ, Scordo JM, Pino PA, Schlesinger LS, Torrelles JB, Turner J.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

HSE Health Protection Research and Guideline Development Unit Weekly Evidence Surveillance 16/02/24

Weekly surveillance report from the HSE Health Protection Research and Guideline Development ...
Health Protection Surveillance Centre (HPSC)
core  

Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii. [PDF]

Vaccines (Basel), 2021
Komine-Aizawa S, Mizuno S, Matsuo K, Namiki T, Hayakawa S, Honda M.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Enhanced influenza vaccination for older adults in Europe: a review of the current situation and expert recommendations for the future

Expert Review of Vaccines
Introduction Influenza causes considerable morbidity and mortality in Europe, particularly among older adults due to comorbidities, as well as immunosenescence and inflammaging, which contribute to a diminished immune response.
Gaëtan Gavazzi, Bertrand Fougère, Olivier Hanon, Isabel Leroux-Roels, Etienne Brochot, Elodie Blanchard, Colin A Russell, Marc Paccalin, Tino F Schwarz   +8 more
doaj   +1 more source

Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice. [PDF]

Infect Immun, 2022
Shaikh MOF, Schaefers MM, Merakou C, DiBlasi M, Bonney S, Liao T, Zurakowski D, Kehl M, Tabor DE, DiGiandomenico A, Priebe GP.   +10 more
europepmc   +1 more source