Results 121 to 130 of about 627,492 (310)

DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus. [PDF]

Viruses, 2022
Liu L, Yin M, Li Y, Su H, Fang L, Sun X, Chang S, Zhao P, Wang Y.   +8 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Welfare Effects of Employment Protection

Employment protection is often related to costs incurred by the firms when they hire a worker.The stability of the employment relationship, enhanced by employment protection, is also favorable to the productivity of the job.We analyze employment ...
Boone, J., Ours, J.C. van, Belot, M.V.K.
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European Enhanced Vehicle-Safety Committee, Status Report for the 18. ESV Conference

, 2014
Developments presented are: Advanced anthropometric adult crash dummies - Side impact protection " Truck underrun protection " Improvement of compatibility " Pedestrian protection " Child ...
Cesari, Dominique, Friedel, Bernd
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Acute Inflammation Confers Enhanced Protection against Mycobacterium tuberculosis Infection in Mice. [PDF]

Microbiol Spectr, 2021
Piergallini TJ, Scordo JM, Pino PA, Schlesinger LS, Torrelles JB, Turner J.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

TAC Panel on Crop Protection Research: Report

, 1990
Report of the TAC Panel on Crop Protection Research, part of the process of considering ICIPE for support by the CGIAR. It was one of seven such panels created as part of the TAC assessment of non associated centers for support from the CGIAR.
CGIAR Technical Advisory Committee Panel on Crop Protection Research
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Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii. [PDF]

Vaccines (Basel), 2021
Komine-Aizawa S, Mizuno S, Matsuo K, Namiki T, Hayakawa S, Honda M.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Todryk, Stephen M., Plebanski Magdalena, Bejon, P, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Urban, B, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Flanagan, KL, Hill, AV, Philip Bejon, Bejon, Philip, Marsh Kevin, Marsh, K, Mwangi, T, Mwangi, Tabitha, Flanagan, Katie, Hill, Adrian V. S., Bejon Philip, Plebanski, M, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin, Todryk, SM, Flanagan, Katie L.   +37 more
core   +1 more source