Results 101 to 110 of about 1,780,158 (303)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Using dark modes for high-fidelity optomechanical quantum state transfer

, 2012
In a recent publication [Y.D. Wang and A.A. Clerk, Phys. Rev. Lett. 108, 153603 (2012)], we demonstrated that one can use interference to significantly increase the fidelity of state transfer between two electromagnetic cavities coupled to a common ...
Aashish A Clerk, Dong C Fiore V Kuzyk M C Tian L Wang H, Gardiner C W, Parkins A S, Regal C A, Safavi-Naeini A H, Ying-Dan Wang   +6 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The PIANOFORTE partnership: Elevating European research for enhanced radiation protection

EPJ Nuclear Sciences & Technologies
The PIANOFORTE partnership (2022–2029) aims to enhance radiation protection for the public, patients, workers, and the environment across various exposure scenarios.
Garnier-Laplace Jacqueline, Gariel Jean-Christophe, Vanhavere Filip, Rauser Florian, Wojcik Andrzej, Ainsbury Elizabeth, Bouffler Simon, Davídková Marie, Kalita Tomasz, Hoeschen Christoph   +9 more
doaj   +1 more source

Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier

Frontiers in Immunology, 2018
Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host.
Ray M. Al-Barazie, Ghada Hassan Bashir, Mohammed M. Qureshi, Yassir A. Mohamed, Ashraf Al-Sbiei, Saeed Tariq, Wim J. Lammers, Basel K. al-Ramadi, Maria J. Fernandez-Cabezudo   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Tackling regulated cell death yields enhanced protection in lung grafts. [PDF]

Theranostics, 2023
Chen Q, Liu X, Liu Z, Zhang S, Chen L, Eguchi S, Alam A, Cahilog Z, Sun Q, Wu L, Chang E, Wang Z, Gu J, Zhao H, Ma D.   +14 more
europepmc   +1 more source

Automated Protection Performance Assessment and Enhancement

Journal of Power and Energy Engineering, 2014
New strategies and methods for assessing the security of protection systems to reduce the risk of unnecessary disturbances and blackouts are the main topic of the present paper. The system behavior of a protection system and network is analyzed and assessed as a whole.
J. Jaeger, X.-P. Liang, R. Krebs, T. Bopp   +3 more
openaire   +1 more source