Results 91 to 100 of about 4,699,722 (297)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2006 Title from cover.; At head of title: State of Connecticut.; "Changing the Balance."; "Pursuant to Connecticut General Statutes Section 22a-228 and 22a-228-1(b) of the Regulations of Connecticut State Agencies (RCSA) ..."--T.p.
Connecticut. Dept. of Environmental Protection.
core
Frontiers in Immunology, 2018 Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host.
Ray M. Al-Barazie +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
According to the United Nations Environment Programme, marine pollution from land-based sources is a major environmental challenge responsible for about 80% of total marine pollution. This form of pollution arises from substances entering the marine environment through land run-off, rivers, pipelines, and atmospheric contamination, leading to adverse ...
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The PIANOFORTE partnership: Elevating European research for enhanced radiation protection
EPJ Nuclear Sciences & TechnologiesThe PIANOFORTE partnership (2022–2029) aims to enhance radiation protection for the public, patients, workers, and the environment across various exposure scenarios.
Garnier-Laplace Jacqueline +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Anti-M1R/B6R antibody characterization and bispecific design for enhanced orthopoxvirus protection
EMBO Molecular MedicineThe global outbreak of the mpox in humans, caused by the mpox virus (MPXV), underscores the urgent need for safe and effective therapeutics. In this study, we characterized the dominant MPXV immunogens, M1R and B6R, by sequencing monoclonal antibodies ...
Runchu Zhao +20 more
doaj +1 more source