Results 31 to 40 of about 1,761,049 (307)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Smartphones, time-lapse and responsible use in the school laboratory [PDF]

open access: yes, 2012
Reports how observing and recording simple biological phenomena over an extended timescale could be enhanced by digital technology, the journey took surprising turns and twists into questions relating to ethics, child protection and reviewing acceptable ...
MacVicar, Graeme, Souter, Nicky
core  

Using dark modes for high-fidelity optomechanical quantum state transfer

open access: yes, 2012
In a recent publication [Y.D. Wang and A.A. Clerk, Phys. Rev. Lett. 108, 153603 (2012)], we demonstrated that one can use interference to significantly increase the fidelity of state transfer between two electromagnetic cavities coupled to a common ...
Aashish A Clerk   +6 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Enhancing Fundamental Rights Protection

open access: yes
The EU should ensure fundamental rights’ compatibility of EU legislation before its adoption. To that effect, we propose three distinct paths to improve the EU control mechanisms. Whilst mechanisms to ensure quality control do exist, primarily in the form of impact assessments, these mostly remain a merely formal exercise.
Gambardella, Ilaria   +6 more
openaire   +2 more sources

Income disparities of burglary risk and security availability during the crime drop. British Journal of Criminology, 51(2), 296-313. [PDF]

open access: yes, 2011
In the past fifteen years volume crimes dropped substantially in most countries with reliable crime trend estimates. In England and Wales domestic burglary fell by 58% between 1995 and 2008/09, the trend levelling off after 2005/6.
A. Tseloni   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Extended Capabilities for a Privacy-Enhanced Participatory Sensing Infrastructure (PEPSI)

open access: yes, 2013
Participatory sensing is emerging as an innovative computing paradigm that targets the ubiquity of always-connected mobile phones and their sensing capabilities.
De Cristofaro, Emiliano   +1 more
core   +1 more source

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