Results 51 to 60 of about 627,492 (310)

Hazards, heritage protection and disasters resilience Competence, Liability and Culpability. Who's the blame?

Archeomatica, 2018
In ordinary circumstances managing cultural heritage is not any easy, yet, lately it turned into a much more challenging job. During the last few decades we assisted to an increased number of disasters caused by events of unprecedented frequency and ...
Claudio Cimino
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of partial and complete protection in malaria cohort studies. [PDF]

, 2013
BACKGROUND: Malaria transmission is highly heterogeneous and analysis of incidence data must account for this for correct statistical inference. Less widely appreciated is the occurrence of a large number of zero counts (children without a malaria ...
Chandramohan, Daniel, Greenwood, Brian M, Paul J Milligan, Cairns, Matthew E, Milligan, Paul J, Brian M Greenwood, Kwaku Asante, Daniel Chandramohan, Asante, Kwaku Poku, Seth Owusu-Agyei, Owusu-Agyei, Seth, Matthew E Cairns   +11 more
core   +1 more source

High-dose influenza vaccine: enhanced protection for the elderly

Expert Review of Vaccines
Introduction Seasonal influenza causes up to 50 million symptomatic cases and 15,000 – 70,000 deaths annually within the European Union. While influenza affects all age groups, adults aged ≥65 years disproportionately experience high rates of influenza ...
Claudia Maria Trombetta, Emanuele Montomoli   +1 more
doaj   +1 more source

Joint Crypto-Stego Scheme for Enhanced Image Protection With Nearest-Centroid Clustering

IEEE Access, 2018
Owing to the exceptional growth of information exchange over open communication channels within the public Internet, confidential transmission of information has become a vital current concern for organizations and individuals.
Amna Shifa, Muhammad S. Afgan, Mamoona N. Asghar, Martin Fleury, Imran Memon, Saima Abdullah, Nadia Rasheed   +6 more
doaj   +1 more source

Self-Enhancement and Self-Protection Motives

, 2012
AbstractPeople desire to maximize the positivity, and minimize the negativity, of their self-views. The tendency to exalt one's virtues and soften one's weaknesses, relative to objective criteria, manifests itself in many domains of human striving. We focus illustratively on three strivings: the self-serving bias (crediting the self for successes but ...
Sedikides, Constantine, Alicke, Mark D.
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Extracting Access Control and Conflict Resolution Policies from European Data Protection Law [PDF]

, 2011
This paper presents the extraction of a legal access control policy and a conflict resolution policy from the EU Data Protection Directive [1]. These policies are installed in a multi-policy authorization infrastructure described in [2, 3].
van Alsenoy, Brendan, Chadwick, David,, Alsenoy, Brendan,, Brendan Van Alsenoy, Fatema, Kaniz, Kaniz Fatema, Chadwick, David W., David W. Chadwick   +7 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source