Results 51 to 60 of about 647,401 (268)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Electrical Conductivity Enhancement and Electronic Applications of 2D Ti3C2Tx MXene Materials

Advanced Materials Interfaces, 2021
In the past 10 years, MXene (transition metal carbides, nitrides, and carbonitrides), a 2D nanomaterial, has become one of the research hotspots with its hydrophilic ends, solution machinability, and excellent electronic, mechanical, and optical ...
Chunyang Qiao, Han Wu, Xiyan Xu, Zhengxin Guan, Wei Ou‐Yang   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Capacitance enhancement by ion-laminated borophene-like layered materials

Nature Communications
Atomically flat two-dimensional networks of boron are attracting attention as post-graphene materials. An introduction of cations between the boron atomic layers can exhibit unique electronic functions that are not achieved by neutral graphene or its ...
Tetsuya Kambe, Masahiro Katakura, Hinayo Taya, Hirona Nakamura, Takuya Yamashita, Masataka Yoshida, Akiyoshi Kuzume, Kaori Akagami, Ryota Imai, Jumpei Kawaguchi, Shigeyuki Masaoka, Shoichi Kubo, Hiroaki Iino, Atsushi Shishido, Kimihisa Yamamoto   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Alternative Plasmonic Materials for Fluorescence Enhancement

The Journal of Physical Chemistry C
Noble metals such as gold and silver have been used extensively for a range of plasmonic applications, including enhancing the fluorescence rate of a dye molecule, as evidenced by numerous experiments over the past two decades. Recently, a variety of doped semiconductors have been proposed as alternative plasmonic materials, exhibiting plasmonic ...
Stavros Athanasiou, Olivier J. F. Martin
openaire   +2 more sources

Giant ZT enhancement in rhombohedral GeTe-based thermoelectric materials

Nature Communications
The peak figure of merit (ZT) of GeTe-based thermoelectric (TE) materials is typically attained in the high-temperature cubic phase, where the inevitable phase transition raises concerns over interfacial instability during operation.
Jincheng Yu, Xiaodong Liu, Yilin Jiang, Chen Chen, Jing-Wei Li, Haihua Hu, Lin Song, Tian Xie, Bin-Bin Ruan, Yu Pan, Guoyu Wang, B. Layla Mehdi, Xiaoyuan Zhou, Jing-Feng Li   +13 more
doaj   +1 more source

In-Depth Characterization of bZIP Genes in the Context of Endoplasmic Reticulum (ER) Stress in Brassica campestris ssp. chinensis

Plants
Numerous studies have been conducted to investigate the genomic characterization of bZIP genes and their involvement in the cellular response to endoplasmic reticulum (ER) stress.
Aliya Ayaz, Abdul Jalal, Xiaoli Zhang, Khalid Ali Khan, Chunmei Hu, Ying Li, Xilin Hou   +6 more
doaj   +1 more source