Results 81 to 90 of about 5,612,960 (265)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Purcell enhancement of the parametric down-conversion in two-dimensional nonlinear materials
APL Photonics, 2019 Ultracompact nonlinear optical devices utilizing two-dimensional (2D) materials and nanostructures are emerging as important elements of photonic circuits.
Mikhail Tokman +6 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Enhanced collective vibrations in granular materials
Soft MatterGranular particles are more collective than colloidal particles. We analytically and numerically studied the dynamics of jammed particles to reveal the underlying mechanism of the collective vibrations of granular particles.
Shihori Koyama +3 more
openaire +3 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
What is Health Flow Male Enhancement?
, 2021 Health Flow Male Enhancement In case you are a man, the last spot you need to disillusion anybody, including yourself, is the room. That is the reason we need to enlighten you concerning Health Flow Male Enhancement pills. This new recipe is a simple way
Health Flow Male Enhancement
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
BuildingsThe use of recycled coarse aggregates (RCA) in concrete production offers significant environmental and economic benefits. However, the high water absorption and low mechanical strength of RCA, caused by residual mortar and internal cracks, severely ...
Jian Wang +7 more
doaj +1 more source
Enhancement of Drought Tolerance in Cucumber Plants by Natural Carbon Materials
Plants, 2019 Stress induced by climate change is a widespread and global phenomenon. Unexpected drought stress has a substantial effect on the growth and productivity of valuable crops.
Tae Yoon Kim +3 more
doaj +1 more source