Results 81 to 90 of about 5,113,822 (314)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Enhanced pyroelectric effect through product property and its applications [PDF]
, 2009 Pyroelectric materials have the ability to generate electrical response when they experience a thermal stimulus. This has lead to their deployment in applications such as Infra-Red detectors/sensors, energy harvesting, and ferroelectric electron ...
Chang, Harrison Hoon Seok
core +2 more sources
Purcell enhancement of the parametric down-conversion in two-dimensional nonlinear materials
APL Photonics, 2019 Ultracompact nonlinear optical devices utilizing two-dimensional (2D) materials and nanostructures are emerging as important elements of photonic circuits.
Mikhail Tokman +6 more
doaj +1 more source
Evaluation of the antimicrobial activity of heat-cure denture base resin materials incorporated with silver nanoparticles [PDF]
, 2019 Background: Poly (Methyl methacrylic acid) based materials are the most widely used for the fabrication of removable complete and partial dentures.
Alla, Rama Krishna +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Enhanced collective vibrations in granular materials
Soft MatterGranular particles are more collective than colloidal particles. We analytically and numerically studied the dynamics of jammed particles to reveal the underlying mechanism of the collective vibrations of granular particles.
Shihori Koyama +3 more
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
BuildingsThe use of recycled coarse aggregates (RCA) in concrete production offers significant environmental and economic benefits. However, the high water absorption and low mechanical strength of RCA, caused by residual mortar and internal cracks, severely ...
Jian Wang +7 more
doaj +1 more source