Results 221 to 230 of about 18,114 (279)

Methionine-enkephalin, leucine-enkephalin, methionine-enkephalin-Arg6-Phe7 and methionine-enkephalin-Arg6-Gly7-Leu8 in human pheochromocytoma

Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
T, Yoshimasa, K, Nakao, Y, Ikeda, M, Sakamoto, M, Suda, H, Imura   +5 more
openaire   +2 more sources

Potent tetrapeptide enkephalins

Life Sciences, 1981
Abstract Small peptides with opiate-like activity have generally had structures closely resembling that of the opioid pentapeptide enkephalin: Tyr-Gly-Gly-Phe-Met-COOH. Single deletions of any one of the amino acids has been demonstrated to reduce opiate activity drastically.
R E, Chipkin, D H, Morris, M G, English, J D, Rosamond, C H, Stammer, E J, York, J M, Stewart   +6 more
openaire   +2 more sources

Enkephalins as immunomodulators

International Journal of Immunopharmacology, 1983
The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. Significant increases in number of survivors were observed in mice treated with enkephalins.
N P, Plotnikoff, G C, Miller
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Biosynthesis of the Enkephalins and Enkephalin-Containing Polypeptides

Annual Review of Pharmacology and Toxicology, 1983
The biochemical characterization of the enkephalins and the enkephalin-containing polypeptides and their biosynthesis has reached an advanced state. From the structural data showing great similarities between human and beef proenkephalin there is strong evidence for physiological roles for some of the extended enkephalins and for at least two of the ...
R V, Lewis, A S, Stern
openaire   +2 more sources

Biochemistry of the enkephalins and enkephalin-containing peptides

Archives of Biochemistry and Biophysics, 1983
The enkephalins are present in many tissues not only as the free pentapeptides, but also as internal sequences in larger polypeptides of varying size. Fourteen enkephalin-containing peptides (EC peptides) from beef adrenal medulla were isolated and sequenced, and the presence of a protein that contained several [Met]enkephalin sequences and one of [Leu]
S, Udenfriend, D L, Kilpatrick
openaire   +2 more sources

Enkephalins and Endorphins

1979
Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
R J, Miller, P, Cuatrecasas
openaire   +2 more sources

Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation

Peptides, 1983
Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
K S, Hui, M, Hui, M, Banay-Schwartz, T, DeGuzman, N, Ling, A, Lajtha   +5 more
openaire   +2 more sources

Acetylcholinesterase converts Met5-enkephalin-containing peptides to Met5-enkephalin

Neuroscience Letters, 1988
Acetylcholinesterase (AChE; E.C. 3.1.1.7) was incubated with a number of enkephalin-containing neuropeptides found in the bovine adrenal medulla. Met5-enkephalin and Leu5-enkephalin were the most stable of the peptides studied, while precursors of Met5-enkephalin were converted to Met5-enkephalin. AChE is therefore capable of limited peptidase activity
M, Dowton, M, Boelen
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Met-enkephalin-arg6-gly7-leu8 exists together with met-enkephalin-arg6-phe7, met-enkephalin and leu-enkephalin in human stomach

Life Sciences, 1983
Studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin A from adrenal medulla and human pheochromocytoma have revealed that this precursor contains 4 copies of methionine-enkephalin(Met-Enk) and one copy each of leu-enkephalin (Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8(Met-Enk-Arg6-Gly7-Leu8) and methionine ...
M, Sakamoto, K, Nakao, T, Yoshimasa, Y, Ikeda, M, Suda, N, Yanaihara, H, Imura   +6 more
openaire   +2 more sources