Results 221 to 230 of about 34,698 (281)
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International Journal of Peptide and Protein Research, 1982
The Gly3residue in Gly2‐ and D‐Ala2‐enkephalins has been replaced by ΔAla3and Ser3in order to examine the effect on binding to the Δ and μ opiate receptors. [D‐Ala2, ΔAla3, Leu5]‐enkephalin maintains most of its receptor binding affinities for both sites.
Yasuyuki Shimohigashi +1 more
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The Gly3residue in Gly2‐ and D‐Ala2‐enkephalins has been replaced by ΔAla3and Ser3in order to examine the effect on binding to the Δ and μ opiate receptors. [D‐Ala2, ΔAla3, Leu5]‐enkephalin maintains most of its receptor binding affinities for both sites.
Yasuyuki Shimohigashi +1 more
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International Journal of Peptide and Protein Research, 1983
Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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Biosynthesis of the Enkephalins and Enkephalin-Containing Polypeptides
Annual Review of Pharmacology and Toxicology, 1983The biochemical characterization of the enkephalins and the enkephalin-containing polypeptides and their biosynthesis has reached an advanced state. From the structural data showing great similarities between human and beef proenkephalin there is strong evidence for physiological roles for some of the extended enkephalins and for at least two of the ...
Alvin S. Stern, Randolph V. Lewis
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Biochemistry of the enkephalins and enkephalin-containing peptides
Archives of Biochemistry and Biophysics, 1983The enkephalins are present in many tissues not only as the free pentapeptides, but also as internal sequences in larger polypeptides of varying size. Fourteen enkephalin-containing peptides (EC peptides) from beef adrenal medulla were isolated and sequenced, and the presence of a protein that contained several [Met]enkephalin sequences and one of [Leu]
Sidney Udenfriend, Daniel L. Kilpatrick
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Enkephalins as immunomodulators
International Journal of Immunopharmacology, 1983The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. Significant increases in number of survivors were observed in mice treated with enkephalins.
N. P. Plotnikoff, Gerald C. Miller
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Journal of Physical Chemistry B, 2014
This paper presents a methodology that allows the fine refinement of the crystal and molecular structure for compounds for which the data deposited in the crystallographic bases are of poor quality.
Tomasz Pawlak, M. Potrzebowski
semanticscholar +1 more source
This paper presents a methodology that allows the fine refinement of the crystal and molecular structure for compounds for which the data deposited in the crystallographic bases are of poor quality.
Tomasz Pawlak, M. Potrzebowski
semanticscholar +1 more source
Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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Synthesis of cyclic and acyclic partial retro-inverso modified enkephalins.
International journal of peptide & protein research, 2009The cyclic partial retro-inverso modified enkephalins, H-Tyr-cyclo[-D-Glu-Gly-gPhe-D-Leu-] (I), H-Tyr-cyclo[-D-A2bu-Gly-gPhe-R&S-mLeu-] (IIf, IIs), and H-Tyr-cyclo[-D-Glu-Gly-Phe-gLeu-] (III), have been synthesized by solution methodology.
J. Berman, M. Goodman
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1979
Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
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Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
openaire +3 more sources