Results 101 to 110 of about 749,466 (300)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Parteneriatul estic: începutul refluxului procesului de extindere a Uniunii Europene? (The Eastern Partnership: the beginning of the ebb for the EU enlargement?) [PDF]

Polis: Revista de Stiinte Politice, 2016
he aim of this paper is to highlight the geopolitical limits and the strategic weakness of the European Union in his approach concerning the enlargement policy and the Neighborhood Policy after the beginning of the crisis in Ukraine. For this reason, the
Gheorghe CIASCAI
doaj  

Trade Diversion in the 'Left-Outs' in the Eastward Enlargement of the European Union [PDF]

I analyze three scenarios including no Eastward enlargement of the EU and the accession of Central European countries including and excluding Slovakia.
Fidrmuc, Jarko
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

CHALLENGES OF THE EUROPEAN UNION BUDGET REFORM [PDF]

Challenges of the Knowledge Society, 2011
At the European Union are presented some concerns regarding the need to review its policies starting with the recommendations for the budget reform and the change of the EU basic policies.
ELENA PADUREAN, EMILIA CAMPEANU, ANDREEA STOIAN   +2 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

CROATIA: THE 28th MEMBER STATE OF THE EUROPEAN UNION [PDF]

Challenges of the Knowledge Society, 2013
In an enlarged European Union of 27 Member States, convinced that the successive enlargements have been a success both for the European Union and the Member States which acceded to it, thus contributing to stability, development and prosperity throughout
DAN VĂTĂMAN
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Stability Through Caution: NATO’S Evolution Under the Doctrine of Strategic Restraint

Social Development & Security
Purpose. To examine NATO’s evolving strategic posture in future, focusing on how the Alliance balances deterrence, defense, and diplomatic restraint in a rapidly changing security environment. Method: Comparative analysis, and synthesis.
Khayal Iskandarov
doaj   +1 more source

The Impact of The European Enlargement and CAP Reforms on Agricultural Markets. Much Ado about Nothing? [PDF]

We analyze the effects of the 2004 CAP reform and EU enlargement on European and world agricultural markets. We compare the results from a CAP reform only and a CAP reform plus enlargement scenarios to a no-enlargement baseline implementing Agenda 2000 ...
Beghin, John C., Dong, Fengxia, Elobeid, Amani E., Fabiosa, Jacinto F., Fuller, Frank H., Matthey, Holger, Tokgoz, Simla, Wailes, Eric J.   +7 more
core   +1 more source