Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Economic Opening up of Russia: Establishment of New EU-RF Trade Relations in View of EU Eastern Enlargement [PDF]
The EU's economic co-operation and political dialogue with Russia take place in many spheres touching the Kaliningrad issue, WTO membership, a war against terrorism, energy dialogue, and the consequences of the EU Eastern Enlargement that took place in ...
Paulina Pospiezna
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The political economy of EU enlargement and the Treaty of Nice [PDF]
The paper applies standard public choice reasoning to the negotiations on EU enlargement and the Treaty of Nice. The starting point is the assumption that accession can only be successfully completed if the interests of decisive actors in present EU ...
Heinemann, Friedrich
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Who is in favor of enlargement? Determinants of support for EU membership in the candidate countries' referenda [PDF]
We analyze support for EU membership as expressed in voting patterns in the candidate countries’ referenda on EU membership, using regional referendum results and individual survey data on voting intentions. We find that favorable individual and regional
Doyle, Orla, Fidrmuc, Jan
core
Autologous Iliac Crest Bone Graft After Anterior Cruciate Ligament Reconstruction Failure in Patients With Both Femoral and Tibial Tunnel Enlargement. [PDF]
Arthrosc TechWu A, He Y, Xiang S, Xiong C, Zhu W.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The EU’s Foreign Policy after the Fifth Enlargement: Any Change in Its Taiwan Policy? [PDF]
On 1 May 2004, the world witnessed the largest expansion in the history of the European Union (EU). This process has lent new weight to the idea of an expanded EU involvement in East Asia.
Günter Schucher
core