Results 71 to 80 of about 436,299 (263)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Influence of the EU enlargement on the agrarian foreign trade development in member states
Agricultural Economics (AGRICECON), 2009 The paper analyses the development of agrarian foreign trade of the EC/EU states in the period 1961-2006. The aim of the analysis is to evaluate the influence of the EC/EU member base enlargement on the development of the value and territorial structure ...
M. Svatoš, L. Smutka
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
EU enlargement and the Common Agricultural Policy
Agricultural Economics (AGRICECON), 2003 The incorporation of the Central and Eastern European Countries (CEECs) to the common agrarian market of the European Union is an entrance the saturated market solving problems with surpluses of main agricultural commodities. That is why an increasing of
V. Bečvářová
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Enlargement of Trade Blocs: National Welfare Effects If Trade Is Liberalized [PDF]
Small countries may benefit from the formation of a trade bloc, since their combined market power will enable them to manipulate the terms of trade. The question of interest is whether countries will benefit from the enlargement of a trading bloc, if ...
Glebe, Thilo W., Salhofer, Klaus
core
EU Enlargement and Technology Transfer to New Member States, November 2005 [PDF]
, 2005 The European Union (EU) accomplished its biggest enlargement process in 2004 in terms of the number of countries, area, and population. This study focuses on the impact of enlargement, the resulting technology transfer on the grain sectors of the New ...
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Sizing It Up: Labor Migration Lessons of the EU Enlargement to 27 [PDF]
While economists were pointing out the advantages of the EU enlargement, politicians and policymakers were raising grave concerns about the significant political and economic differences between the newcomer states (EU12) and the "old Europe" of EU15 ...
Constant, Amelie F.
core
Building the new Europe : soft security and organised crime in EU enlargement [PDF]
, 2009 A thesis submitted in partial fulfilment of therequirements of the University of Wolverhampton for the degree of Doctor of PhilosophyThis thesis examines the policy and politics of the fight against organised crime in the process of the European Union’s ...
Gachevska, Katerina
core +3 more sources