Results 231 to 240 of about 177,036 (313)

Dl‐3‐n‐Butylphthalide Promotes Cortical Angiogenesis via Akt/GSK‐3β Signaling in Ischemic Stroke Mice

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
NBP promotes post‐stroke angiogenesis by upregulating VEGF through activation of the Akt/GSK3β pathway. NBP enhances vascular maturation via increased pericyte and astrocyte coverage of cerebral microvessels. NBP facilitates cerebral blood flow and augments cortical vasodilation in ischemic stroke mice.
Lan Zhang, Shanshan Wei, Jian Zhang, Rong Chen, Jiangyong Miao, Lina Wang, Peipei Zhang, Wenyan Shang, Renhao Xu, Xiangjian Zhang, Cong Zhang   +10 more
wiley   +1 more source

FAD012, a Ferulic Acid Derivative, Preserves Cerebral Blood Flow and Blood-Brain Barrier Integrity in the Rat Photothrombotic Stroke Model. [PDF]

Biomedicines
Sugoh H, Matsuzaki H, Takayama J, Iwata N, Xuan M, Yuan B, Sakamoto T, Okazaki M.   +7 more
europepmc   +1 more source

Phenolic Metabolites Protocatechuic Acid and Vanillic Acid Improve Nitric Oxide Bioavailability via the Akt-eNOS Pathway in Response to TNF-α Induced Oxidative Stress and Inflammation in Endothelial Cells [PDF]

Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Stephen J. Bailey, Harprit Singh, Mariasole Da Boit   +5 more
openalex   +1 more source

The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication. [PDF]

Exerc Sport Sci Rev
Craige S.
europepmc   +1 more source

Transcription of the Human β Enolase Gene (ENO-3) Is Regulated by an Intronic Muscle-Specific Enhancer That Binds Myocyte-Specific Enhancer Factor 2 Proteins and Ubiquitous G-Rich-Box Binding Factors

, 1995
Salvatore Feo, Vincenzo Antona, Giovanna Barbieri, Rosa Passantino, Larissa Calı̀, Agata Giallongo   +5 more
openalex   +2 more sources

Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Pulmonary vascular disease in patients with single ventricular heart disease is a significant source of morbidity and mortality. Utilizing an integrated investigative platform that included a novel ovine Glenn model, we demonstrate early pulmonary vascular endothelial dysfunction with the initiation of the nonpulsatile pulmonary blood flow that ...
Jonathan Hyde, Michael A. Smith, Naveen Swami, John H. Hwang, Yenchun Chao, Jason Boehme, Gary W. Raff, Casper Noah Nilsson, Wenhui Gong, Gail H. Deutsch, Eric G. Johnson, Ting Wang, Stephen M. Black, Sanjeev A. Datar, Emin Maltepe, Jeffrey R. Fineman   +15 more
wiley   +1 more source

Active Endothelial Inactivation of Hyperpermeability: The Role of Nitric Oxide-Driven cAMP/Epac1 Signaling. [PDF]

J Cardiovasc Dev Dis
Lillo MA, Burboa PC, Durán WN.
europepmc   +1 more source

Food‐Herb Dual‐Function in Astragali Radix‐Poria‐Rheum: Network Pharmacology and Database Mining for Diabetic Kidney Disease Mechanisms Exploration

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study identified the core food‐herb formula “Astragali Radix‐Poria‐Rheum (Ast‐Por‐Rhe)” for Diabetic Kidney Disease (DKD) through data mining of clinical prescriptions. Integrated network pharmacology and in vivo validation revealed that this formula ameliorates renal injury and insulin resistance in DKD rats by activating the IRS1/PI3K/AKT ...
Meizi Wang, Weizhong Li, Qiong Cheng, Jiayu Sun, Cheng Cheng, Nana Wang, Ping Zhou, Min Zha, Yufeng Yang   +8 more
wiley   +1 more source

Exploring the role of febuxostat's drug target XOR in erectile dysfunction: insights from human genetics and rat models. [PDF]

Front Med (Lausanne)
Chen Z, Li Y, Meng C, Li X, Liao H, Li X, Zeng Y, Li X, Zhou T, Deng Q.   +9 more
europepmc   +1 more source

Multidimensional Evaluation of Vascular Dysfunction in Diabetic Erectile Dysfunction: Synergistic Application of ICP Measurement, Laser Speckle Blood Perfusion Imaging, and Ex Vivo Microvascular Tension Measurement. [PDF]

Am J Mens Health
Pan S, Ma H, Zeng Z, Wang J, Huang J, Ma J.   +5 more
europepmc   +1 more source