Results 1 to 10 of about 58,072 (277)

Localization of nitric oxide synthase type III in the internal thoracic and radial arteries and the great saphenous vein: a comparative immunohistochemical study [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2003
Endothelial nitric oxide synthase type III is the key enzyme of the nitric oxide production in the vessel wall. In this study the localization of endothelial nitric oxide synthase type III within the wall of the human internal thoracic and radial arteries and the great saphenous vein was investigated.Specimens were harvested from 23 patients undergoing
Gaudino, M., Toesca Di Castellazzo, Amelia, Maggiano, N., Pragliola, C., Possati, G.   +4 more
openaire   +5 more sources

Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion

mBio, 2016
Salmonella enterica serovar Typhimurium can cross the epithelial barrier using either the invasion-associated type III secretion system (T3SS-1) or a T3SS-1-independent mechanism that remains poorly characterized.
Fabian Rivera-Chávez, Christopher A. Lopez, Lillian F. Zhang, Lucía García-Pastor, Alfredo Chávez-Arroyo, Kristen L. Lokken, Renée M. Tsolis, Sebastian E. Winter, Andreas J. Bäumler   +8 more
doaj   +1 more source

Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Journal of Translational Medicine, 2021
Background Dyslipidaemia is a major risk factor for atherosclerosis and cardiovascular diseases. The molecular mechanisms that translate dyslipidaemia into atherogenesis and reliable markers of its progression are yet to be fully elucidated.
Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki, Ryszard T. Smolenski   +8 more
doaj   +1 more source

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Journal of Translational Medicine, 2018
Background Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns.
Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong   +4 more
doaj   +1 more source

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice [PDF]

Stroke, 2000
Background and Purpose —Thrombosis superimposed on atherosclerosis causes approximately two thirds of all brain infarctions. We previously demonstrated that statins protect from cerebral ischemia by upregulation of endothelial type III nitric oxide synthase (eNOS), but the downstream mechanisms have not been determined ...
U, Laufs, K, Gertz, P, Huang, G, Nickenig, M, Böhm, U, Dirnagl, M, Endres   +6 more
openaire   +2 more sources

Type III Secretion Protein, PcrV, Impairs Pseudomonas aeruginosa Biofilm Formation by Increasing M1 Macrophage-Mediated Anti-bacterial Activities

Frontiers in Microbiology, 2020
Pseudomonas aeruginosa biofilms employ a variety of strategies to hijack the host immune defense system to achieve chronic infection. However, the bacterial components that are involved in this process are not yet fully understood.
Hua Yu, Junzhi Xiong, Jing Qiu, Xiaomei He, Halei Sheng, Qian Dai, Defeng Li, Rong Xin, Lu Jiang, Qiaoqiao Li, Qian Chen, Jin Peng, Maolin Wang, Xiancai Rao, Kebin Zhang   +14 more
doaj   +1 more source

Antitumoral gene-based strategy involving nitric oxide synthase type III overexpression in hepatocellular carcinoma

Gene Therapy, 2015
Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoblastoma cells. The study developed gene therapy designed to specifically overexpress NOS-3 in cultured hepatoma cells, and in tumors derived from orthotopically implanted tumor cells in fibrotic livers. Liver
De la Rosa, Angel J., Rodríguez Hernández, María Angeles, González Ojeda, Raúl, Romero Brufau, Santiago, Navarro-Villarán, Elena, Barrera Pulido, Lidia, Pereira, Sheila, Marín, Luis M., López Bernal, F., Álamo, José M., Gómez Bravo, Miguel A., Padillo, Francisco J., Muntané Relat, Jordi   +12 more
openaire   +3 more sources

Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases [PDF]

Journal of Biological Chemistry, 2000
Endothelial nitric-oxide synthase (NOS-III) is defined as being strictly dependent on Ca(2+)/calmodulin (CaM) for activity, although NO release from endothelial cells has been reported to also occur at intracellular free Ca(2+) levels that are substimulatory for the purified enzyme.
E, Butt, M, Bernhardt, A, Smolenski, P, Kotsonis, L G, Fröhlich, A, Sickmann, H E, Meyer, S M, Lohmann, H H, Schmidt   +8 more
openaire   +2 more sources

Chimeras of Nitric-oxide Synthase Types I and III Establish Fundamental Correlates between Heme Reduction, Heme-NO Complex Formation, and Catalytic Activity [PDF]

Journal of Biological Chemistry, 2001
Neuronal nitric-oxide synthase (nNOS or NOS I) and endothelial NOS (eNOS or NOS III) differ widely in their reductase and nitric oxide (NO) synthesis activities, electron transfer rates, and propensities to form a heme-NO complex during catalysis.
S, Adak, K S, Aulak, D J, Stuehr
openaire   +2 more sources

Scientific validation of anti-arthritic effect of Kashayams – A polyherbal formulation in collagen induced arthritic rats

Journal of Ayurveda and Integrative Medicine, 2021
Background: Toll-like receptor-4 (TLR-4) mediates activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) resulting in induction of proinflammatory genes such as that encoding tumor necrosis factor-α (TNF-α) and interleukin ...
Aswathy I. S., Santhi Krishnan, Jasmine Peter, Vidya Sabu, A. Helen   +4 more
doaj   +1 more source