Results 1 to 10 of about 59,882 (144)
Redox Biology, 2015 Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoma cells.
Raúl González +10 more
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Combined metabolic stress and nitric oxide synthase inhibition induces tissue-specific remodeling across cardiovascular and hematopoietic compartments during obesity [PDF]
Frontiers in Cardiovascular MedicineObesity-associated cardiometabolic disease is characterized by tissue-specific remodeling across cardiovascular, immune, and skeletal tissues. However, the integrated effects of combined metabolic stress and nitric oxide synthase (NOS) inhibition on ...
Julia Drolet +5 more
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Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain [PDF]
Memorias do Instituto Oswaldo Cruz, 2021 BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production.
João Cláudio Damasceno-Sá +9 more
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Association of endothelial nitric oxide synthase gene (G894T) polymorphism and hypertension in diabetic Bataknese patients [PDF]
Medicinski Glasnik, 2020 Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.
Jelita Siregar +4 more
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The Journal of Maternal-Fetal & Neonatal Medicine, 2023 Introduction Three common endothelial nitric oxide synthase (eNOS) gene variants are existed such as; G-894T, T-786C, and variable number tandem repeats in intron-4 (VNTR intron-4) which has been proposed to be linked with PE.
Endalamaw Tesfa +3 more
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Medicina, 2023 Background and Objectives: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors.
Alejandro Marín-Medina +3 more
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Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine [PDF]
Journal of Biological Chemistry, 1995 Endothelial synthesis of NO is catalyzed by constitutive NO synthase type III (NOS-III). NOS-III has been thought to be regulated mainly at the level of enzyme activity by intracellular calcium. We report that in human umbilical vein endothelial cells lysophosphatidylcholine (lyso-PC), a component of atherogenic lipoproteins and atherosclerotic lesions,
A, Zembowicz, J L, Tang, K K, Wu
openaire +2 more sources
Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III [PDF]
Journal of Biological Chemistry, 2002 Homodimer formation activates all nitric-oxide synthases (NOSs). It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg. Here we compared three NOSoxy isozymes regarding dimer strength, interface composition, and the ability of L-Arg and H4B to ...
Koustubh, Panda +5 more
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Frontiers in Cell and Developmental Biology, 2022 Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi +20 more
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Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice.Materials and Methods: The sepsis-induced AKI model was constructed in the wild-type and SIRT3 ...
Heng Fan +3 more
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