Results 1 to 10 of about 57,731 (238)

Nitric Oxide Synthase Type III Overexpression By Gene Therapy Exerts Antitumoral Activity In Mouse Hepatocellular Carcinoma

Redox Biology, 2015
Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoma cells.
Raúl González, Ángel J. De la Rosa, Santiago Romero-Brufau, Lydia Barrera-Pulido, Francisco Gallardo-Chamizo, Sheila Pereira, Luís M. Marín, José M. Álamo, Ángeles Rodríguez-Hernández, Francisco J. Padillo, Jordi Muntané   +10 more
doaj   +3 more sources

Aerobic exercise-induced irisin secretion is associated with improved endothelial function and reduced atherosclerosis in ApoE-deficient mice [PDF]

Scientific Reports
Exercise training improves endothelial function and reduces vascular inflammation. However, whether aerobic exercise training-induced secretion of irisin, a myokine cleaved from fibronectin type III domain-containing protein 5 (FNDC5), is associated with
Kenichiro Inoue, Shumpei Fujie, Masataka Uchida, Reita Ito, Kotaro Nakao, Michiko Kanemoto, Motoyuki Iemitsu   +6 more
doaj   +2 more sources

[3 H]L-NG-Nitroarginine Binding after Transient Focal Ischemia and NMDA-Induced Excitotoxicity in Type I and Type III Nitric Oxide Synthase Null Mice [PDF]

Journal of Cerebral Blood Flow and Metabolism, 1997
We investigated the density and distribution of nitric oxide synthase (NOS) binding by quantitative autoradiography using [3H]L-NG-nitroarginine ([3H]L-NNA) after transient focal ischemia or intrastriatal injection of N-methyl-D-aspartate (NMDA) in wild-type (SV-129 and C57black/6) and type I (neuronal) and type III (endothelial) NOS-deficient mice ...
Christian Waeber, Cenk Ayata, Michael Moskowitz   +2 more
exaly   +3 more sources

Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain [PDF]

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production.
João Cláudio Damasceno-Sá, Fernanda Silva de Souza, Thiago Alves Teixeira dos Santos, Fábio Conceição de Oliveira, Maria de Fátima Sarro da Silva, Raul Ramos Furtado Dias, Wanderley de Souza, Andrea Cristina Veto Arnholdt, Sergio Henrique Seabra, Renato Augusto DaMatta   +9 more
doaj   +1 more source

Association of endothelial nitric oxide synthase gene (G894T) polymorphism and hypertension in diabetic Bataknese patients [PDF]

Medicinski Glasnik, 2020
Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.
Jelita Siregar, Ratna Akbari Ganie, Dharma Lindarto, Erna Mutiara, Delfitri Munir   +4 more
doaj   +1 more source

Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the NOS3 Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients

Medicina, 2023
Background and Objectives: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors.
Alejandro Marín-Medina, José Juan Gómez-Ramos, Norberto Mendoza-Morales, Luis Eduardo Figuera-Villanueva   +3 more
doaj   +1 more source

Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine [PDF]

Journal of Biological Chemistry, 1995
Endothelial synthesis of NO is catalyzed by constitutive NO synthase type III (NOS-III). NOS-III has been thought to be regulated mainly at the level of enzyme activity by intracellular calcium. We report that in human umbilical vein endothelial cells lysophosphatidylcholine (lyso-PC), a component of atherogenic lipoproteins and atherosclerotic lesions,
A, Zembowicz, J L, Tang, K K, Wu
openaire   +2 more sources

Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice.Materials and Methods: The sepsis-induced AKI model was constructed in the wild-type and SIRT3 ...
Heng Fan, Jian-wei Le, Min Sun, Jian-hua Zhu   +3 more
doaj   +1 more source

Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III [PDF]

Journal of Biological Chemistry, 2002
Homodimer formation activates all nitric-oxide synthases (NOSs). It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg. Here we compared three NOSoxy isozymes regarding dimer strength, interface composition, and the ability of L-Arg and H4B to ...
Koustubh, Panda, Robin J, Rosenfeld, Sanjay, Ghosh, Abigail L, Meade, Elizabeth D, Getzoff, Dennis J, Stuehr   +5 more
openaire   +2 more sources

The Antitumoral Effect of Paris Saponin II on Head and Neck Squamous Cell Carcinomas Mediated via the Nitric Oxide Metabolic Pathway

Frontiers in Cell and Developmental Biology, 2022
Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi, Wenwen Qi, Fangyuan Zhu, Min Wang, Zhenxiao Teng, Zhenxiao Teng, Runtong Xu, Yue Xi, Qiu Meng, Xinhao Wu, Xinhao Wu, Hui Zhao, Min Ma, Xiaozhi Hou, Baowei Wang, Xiaoming Li, Chengcheng Liu, Xiang Zhang, Fenglei Xu, Ming Xia, Ming Xia   +20 more
doaj   +1 more source