Results 21 to 30 of about 10,767,649 (278)

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

Phototriggering Nitric Oxide Synthase from Geobacillus stearothermophilus [PDF]

, 2012
Nitric oxide synthases (NOS) produce L-citrulline and nitric oxide (NO) in two turnovers from L-arginine via the bound intermediate, N-hydroxy-L-arginine.
Keller, Gretchen Eva, Gretchen Eva Keller   +1 more
core   +1 more source

Implementation of pro- and anti-inflammatory mechanisms of sirtuin-1 in patients with chronic obstructive pulmonary disease and chronic coronary syndrome and their combination

Zaporožskij Medicinskij Žurnal, 2023
One of the key pathogenetic aspects of chronic obstructive pulmonary disease (COPD) and chronic coronary syndrome (CCS) is endothelial dysfunction.
Ya. V. Chobanu, T. O. Ilashchuk
doaj   +1 more source

L-NA-Sensitive rCBF Augmentation during Vibrissal Stimulation in Type III Nitric Oxide Synthase Mutant Mice [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1996
Regional cerebral blood flow (rCBF) was studied in type III nitric oxide (NO) synthase (endothelial, eNOS) mutant and wild type mice during mechanical whisker stimulation before and after nitro-L-arginine (L-NA) superfusion using the closed cranial window technique. rCBF increased equally in cortical barrel fields in both strains during stimulation, as
C, Ayata, J, Ma, W, Meng, P, Huang, M A, Moskowitz   +4 more
openaire   +2 more sources

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin, Lioté, Frédéric, Rey, Christian, Ea, Hang-Korng   +3 more
core   +1 more source

Resveratrol Prevented Lipopolysaccharide-Induced Endothelial Dysfunction in Rat Thoracic Aorta Through Increased eNOS Expression

Balkan Medical Journal, 2016
Background: The cardiovascular benefits of Resveratrol (RVT) have been well established by previous experimental and clinical studies. Aims: The goal of this study was to test the effectiveness of RVT administration on the impaired endothelial ...
Seda Sultan Uğurel, Selvinaz Dalaklıoğlu, Arda Taşatargil, Nilay Kuşçu, Çiler Çelik Özenci   +4 more
doaj   +1 more source

Localization of nitric oxide synthase type III in the internal thoracic and radial arteries and the great saphenous vein: a comparative immunohistochemical study [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2003
Endothelial nitric oxide synthase type III is the key enzyme of the nitric oxide production in the vessel wall. In this study the localization of endothelial nitric oxide synthase type III within the wall of the human internal thoracic and radial arteries and the great saphenous vein was investigated.Specimens were harvested from 23 patients undergoing
Gaudino, M., Toesca Di Castellazzo, Amelia, Maggiano, N., Pragliola, C., Possati, G.   +4 more
openaire   +4 more sources

Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion

mBio, 2016
Salmonella enterica serovar Typhimurium can cross the epithelial barrier using either the invasion-associated type III secretion system (T3SS-1) or a T3SS-1-independent mechanism that remains poorly characterized.
Fabian Rivera-Chávez, Christopher A. Lopez, Lillian F. Zhang, Lucía García-Pastor, Alfredo Chávez-Arroyo, Kristen L. Lokken, Renée M. Tsolis, Sebastian E. Winter, Andreas J. Bäumler   +8 more
doaj   +1 more source

Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects [PDF]

, 2004
Background: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic heart disease (IHD), but data from published studies with individually low statistical power are conflicting.
Humphries, S.E., Bautista, Leonelo E, Humphries, Steve E, Bautista, L.E., Casas, J.P., Hingorani, Aroon D, Casas, Juan P, Hingorani, A.D., J. P. Casas   +8 more
core   +1 more source

Nitric oxide-mediated modulation of the murine locomotor network [PDF]

, 2014
CD was supported by a BBSRC studentshipSpinal motor control networks are regulated by neuromodulatory systems to allow adaptability of movements. The present study aimed to elucidate the role of nitric oxide (NO) in the modulation of mammalian spinal ...
Miles, Gareth Brian, Foster, Joshua David, Sillar, Keith Thomas, Dunford, Catherine   +3 more
core   +1 more source