Results 21 to 30 of about 127,382 (281)

Nitric oxide synthase:non-canonical expression patterns [PDF]

, 2014
Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns ...
Mattila, Joshua, Thomas, Anita C
core   +5 more sources

Antitumoral gene-based strategy involving nitric oxide synthase type III overexpression in hepatocellular carcinoma

Gene Therapy, 2015
Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoblastoma cells. The study developed gene therapy designed to specifically overexpress NOS-3 in cultured hepatoma cells, and in tumors derived from orthotopically implanted tumor cells in fibrotic livers. Liver
De la Rosa, Angel J., Rodríguez Hernández, María Angeles, González Ojeda, Raúl, Romero Brufau, Santiago, Navarro-Villarán, Elena, Barrera Pulido, Lidia, Pereira, Sheila, Marín, Luis M., López Bernal, F., Álamo, José M., Gómez Bravo, Miguel A., Padillo, Francisco J., Muntané Relat, Jordi   +12 more
openaire   +3 more sources

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +5 more sources

Activation of Type III Nitric Oxide Synthase in Astrocytes Following a Neurotropic Viral Infection

Virology, 1996
Type III nitric oxide synthase (type III NOS), also known as endothelial cell nitric oxide synthase (eNOS or ecNOS or NOS-3), is a constitutively expressed, calcium- and calmodulin-dependent, isoform of NOS. Its expression has been localized to endothelial cells and a subset of neurons in the brain.
Barna, Maria, Komatsu, Takashi, Reiss, Carol S.   +2 more
openaire   +2 more sources

Signaling from blood vessels to CNS axons through nitric oxide [PDF]

, 2006
Brain function is usually perceived as being performed by neurons with the support of glial cells, the network of blood vessels situated nearby serving simply to provide nutrient and to dispose of metabolic waste.
Bartus, K, Dooldeniya, C, Garthwaite, G, Garthwaite, J, Goodwin, D, Kollb-Sielecka, M, Malcolm, D   +6 more
core   +1 more source

Resveratrol Prevented Lipopolysaccharide-Induced Endothelial Dysfunction in Rat Thoracic Aorta Through Increased eNOS Expression

Balkan Medical Journal, 2016
Background: The cardiovascular benefits of Resveratrol (RVT) have been well established by previous experimental and clinical studies. Aims: The goal of this study was to test the effectiveness of RVT administration on the impaired endothelial ...
Seda Sultan Uğurel, Selvinaz Dalaklıoğlu, Arda Taşatargil, Nilay Kuşçu, Çiler Çelik Özenci   +4 more
doaj   +1 more source

Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases [PDF]

Journal of Biological Chemistry, 2000
Endothelial nitric-oxide synthase (NOS-III) is defined as being strictly dependent on Ca(2+)/calmodulin (CaM) for activity, although NO release from endothelial cells has been reported to also occur at intracellular free Ca(2+) levels that are substimulatory for the purified enzyme.
E, Butt, M, Bernhardt, A, Smolenski, P, Kotsonis, L G, Fröhlich, A, Sickmann, H E, Meyer, S M, Lohmann, H H, Schmidt   +8 more
openaire   +2 more sources

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice [PDF]

Stroke, 2000
Background and Purpose —Thrombosis superimposed on atherosclerosis causes approximately two thirds of all brain infarctions. We previously demonstrated that statins protect from cerebral ischemia by upregulation of endothelial type III nitric oxide synthase (eNOS), but the downstream mechanisms have not been determined ...
U, Laufs, K, Gertz, P, Huang, G, Nickenig, M, Böhm, U, Dirnagl, M, Endres   +6 more
openaire   +2 more sources

Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion

mBio, 2016
Salmonella enterica serovar Typhimurium can cross the epithelial barrier using either the invasion-associated type III secretion system (T3SS-1) or a T3SS-1-independent mechanism that remains poorly characterized.
Fabian Rivera-Chávez, Christopher A. Lopez, Lillian F. Zhang, Lucía García-Pastor, Alfredo Chávez-Arroyo, Kristen L. Lokken, Renée M. Tsolis, Sebastian E. Winter, Andreas J. Bäumler   +8 more
doaj   +1 more source