Results 21 to 30 of about 58,072 (277)
Frontiers in Cell and Developmental Biology, 2022 Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi +20 more
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Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III [PDF]
Journal of Biological Chemistry, 2002 Homodimer formation activates all nitric-oxide synthases (NOSs). It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg. Here we compared three NOSoxy isozymes regarding dimer strength, interface composition, and the ability of L-Arg and H4B to ...
Koustubh, Panda +5 more
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Adventitial Collagen Cross-Linking by Glutaraldehyde Reinforcing Human Saphenous Vein - Implication for Coronary Artery Bypass Grafting [PDF]
Brazilian Journal of Cardiovascular Surgery, 2022 Introduction: A weak venous wall is one of the major reasons contributing to vein graft failure after coronary artery bypass grafting (CABG). We investigated whether adventitial collagen cross-linking by glutaraldehyde reinforces venous wall, preserving ...
Changcheng Liu +4 more
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Animals, 2022 Ovine toxoplasmosis is one the most relevant reproductive diseases in sheep. The genetic variability among different Toxoplasma gondii isolates is known to be related to different degrees of virulence in mice and humans, but little is known regarding its
Raquel Vallejo +6 more
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Increased renal expression of nitric oxide synthase type III in cirrhotic rats with ascites [PDF]
Hepatology, 1998 This article assesses the circulating levels of l-arginine, the renal response to l-arginine infusion, and the renal expression of inducible and constitutive nitric oxide synthase (NOS II and NOS III, respectively) in cirrhotic rats with ascites.
M, Bosch-Marcé +9 more
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Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH)
Jian-Min Xiao, Ji-Jia Wang, Li-Li Sun
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Zaporožskij Medicinskij Žurnal, 2023 One of the key pathogenetic aspects of chronic obstructive pulmonary disease (COPD) and chronic coronary syndrome (CCS) is endothelial dysfunction.
Ya. V. Chobanu, T. O. Ilashchuk
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Nitric oxide synthase:non-canonical expression patterns [PDF]
, 2014 Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns ...
Anita C. Thomas +8 more
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Haematologica, 2011 Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano +10 more
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]
, 2005 Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin +3 more
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