Results 11 to 20 of about 127,382 (281)

Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III [PDF]

Journal of Biological Chemistry, 2002
Homodimer formation activates all nitric-oxide synthases (NOSs). It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg. Here we compared three NOSoxy isozymes regarding dimer strength, interface composition, and the ability of L-Arg and H4B to ...
Koustubh, Panda, Robin J, Rosenfeld, Sanjay, Ghosh, Abigail L, Meade, Elizabeth D, Getzoff, Dennis J, Stuehr   +5 more
openaire   +2 more sources

Increased renal expression of nitric oxide synthase type III in cirrhotic rats with ascites [PDF]

Hepatology, 1998
This article assesses the circulating levels of l-arginine, the renal response to l-arginine infusion, and the renal expression of inducible and constitutive nitric oxide synthase (NOS II and NOS III, respectively) in cirrhotic rats with ascites.
M, Bosch-Marcé, M, Morales-Ruiz, W, Jiménez, N, Bordas, M, Solé, J, Ros, R, Deulofeu, V, Arroyo, F, Rivera, J, Rodés   +9 more
openaire   +2 more sources

Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH)
Jian-Min Xiao, Ji-Jia Wang, Li-Li Sun
doaj   +1 more source

Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes [PDF]

Journal of Biological Chemistry, 1995
Nitric oxide synthase (NOS) isoforms are discovered in an increasing variety of cell types with different roles in signaling. The inducible NOS (i.e. iNOS or NOS II) is expressed in cardiac myocytes in response to specific cytokines. Independent of iNOS induction, however, receptor-dependent signaling is modulated by a constitutive nitric oxide (NO ...
J L, Balligand, L, Kobzik, X, Han, D M, Kaye, L, Belhassen, D S, O'Hara, R A, Kelly, T W, Smith, T, Michel   +8 more
openaire   +2 more sources

L-NA-Sensitive rCBF Augmentation during Vibrissal Stimulation in Type III Nitric Oxide Synthase Mutant Mice [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1996
Regional cerebral blood flow (rCBF) was studied in type III nitric oxide (NO) synthase (endothelial, eNOS) mutant and wild type mice during mechanical whisker stimulation before and after nitro-L-arginine (L-NA) superfusion using the closed cranial window technique.
C, Ayata, J, Ma, W, Meng, P, Huang, M A, Moskowitz   +4 more
openaire   +2 more sources

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model [PDF]

, 2020
2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Cappello F., Daca A., Gorska-Ponikowska M., Kuban-Jankowska A., Luu H. H., Marino Gammazza A., Wierzbicka J. M., Wozniak M., Zmijewski M. A.   +8 more
core   +1 more source

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

Implementation of pro- and anti-inflammatory mechanisms of sirtuin-1 in patients with chronic obstructive pulmonary disease and chronic coronary syndrome and their combination

Zaporožskij Medicinskij Žurnal, 2023
One of the key pathogenetic aspects of chronic obstructive pulmonary disease (COPD) and chronic coronary syndrome (CCS) is endothelial dysfunction.
Ya. V. Chobanu, T. O. Ilashchuk
doaj   +1 more source

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]

, 2006
Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Garthwaite, J, Hopper, RA
core   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source